# Validation of a pediatric thrombosis risk assessment model and characterization of bleeding in hospitalized children through the Children's Hospital Acquired Thrombosis (CHAT) Consortium

> **NIH NIH K23** · CHILDREN'S HOSPITAL OF LOS ANGELES · 2022 · $1

## Abstract

PROJECT SUMMARY/ABSTRACT
Venous thromboembolism (VTE), a serious and life-threatening condition, has increased in incidence for
hospitalized pediatric patients by 70-200%. This has led to increased morbidity, mortality and longer
hospitalizations, and is thought to be due to more effective care of children with serious and life-threatening
disorders. Unfortunately, it is unclear which children are at the highest risk of hospital acquired (HA) VTE and
how to prevent these events due to many studies being single center with small case numbers. This study
addresses the critical need to identify children at a high risk of HA-VTE using a risk assessment model
(RAM), but a low risk of bleeding. This cohort will be used as the target population for trials evaluating the
efficacy and safety of prophylactic anticoagulation in order to progress towards the long term goal of HA-VTE
prevention in children. The overall objectives of this study are to (1) prospectively validate a pediatric HA-VTE
RAM created through Dr. Jaffray’s multi-center Children’s Hospital Acquired Thrombosis (CHAT) Consortium
using a case-control study design and electronic medical record review (EMR); (2) evaluate the incidence and
characterization of bleeding in hospitalized children on and off anticoagulation through EMR review; and (3)
explore barriers to provider engagement with RAM implementation by conducting focus groups and semi-
structured interviews of inpatient medical teams using qualitative thematic analysis strategies. To achieve
these research aims, Dr. Jaffray has the immediate career goals to obtain new knowledge, skills, and
experience that will allow her to (1) analyze data from large datasets from multicenter studies and build and
validate risk models through multivariate analysis; (2) develop qualitative research skills to design and analyze
focus groups and semi-structured interviews; and (3) acquire the knowledge to plan and conduct randomized
controlled trials. Achieving these career goals will support her long term career goal of becoming an
independently funded, leader in the effort to determine efficacious and safe VTE prevention strategies in children
through multicenter randomized controlled trials. Dr. Jaffray will accomplish her research and training aims with
the support of her primary mentor, Dr. Guy Young (pediatric thrombosis clinical research), and co-mentors,
Dr. Neil Goldenberg (pediatric clinical trial research), Dr. Ernest Amankwah (biostatics), Dr. Neil Zakai (adult
thrombosis clinical research) and Dr. Elizabeth Burner (qualitative research). Dr. Jaffray’s plan for career
development is enhanced by the outstanding research environment at Children’s Hospital Los Angeles and The
University of Southern California, which provides junior faculty members with numerous didactic and training
opportunities designed specifically to facilitate the transition to research career independence. By completing
her research and training aims, Dr. Jaffray will ta...

## Key facts

- **NIH application ID:** 10426594
- **Project number:** 1K23HL163330-01
- **Recipient organization:** CHILDREN'S HOSPITAL OF LOS ANGELES
- **Principal Investigator:** Julie Ann Jaffray
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1
- **Award type:** 1
- **Project period:** 2022-08-01 → 2022-08-02

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10426594

## Citation

> US National Institutes of Health, RePORTER application 10426594, Validation of a pediatric thrombosis risk assessment model and characterization of bleeding in hospitalized children through the Children's Hospital Acquired Thrombosis (CHAT) Consortium (1K23HL163330-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10426594. Licensed CC0.

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