# Development of Advanced MRI for the Thoracolumbar Spinal Cord for Clinical Application

> **NIH NIH K01** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2022 · $155,578

## Abstract

PROJECT SUMMARY
 In multiple sclerosis (MS), an estimated 40% of spinal cord (SC) lesions are located in the thoracic and
lumbar segments of the SC. These regions of the SC are associated with lower limb and bladder function, the
most prevalent targets for neurological deficits in MS, but the thoracolumbar SC is significantly understudied
and lesions here are rarely identified with clinical magnetic resonance imaging (MRI) protocols. Conventional
clinical MRI for the thoracolumbar SC lacks sensitivity to lesions and microscopic pathology that may drive
impairment, and is unable to discern the extent of demyelination or possible altered function of the lower cord.
The overarching goal of this project is to develop and optimize MRI methods for quantitative characterization
of tissue structure and function in the thoracolumbar SC in patients with MS. I will complete this goal in three
aims: Aim 1) Develop and optimize anatomical, diffusion, and resting-state functional MRI methods for the
thoracolumbar SC at clinical field strength (3T), Aim 2) Quantify the reproducibility of the thoracolumbar MRI
protocol in healthy volunteers and characterize biological variation (e.g. age and sex differences) in
thoracolumbar cord structure and function, and Aim 3) Apply the multimodal MRI toolset to study relationships
between MRI indices, biological variables (age, sex), and clinical measures of lower limb and bladder
dysfunction in MS patients. Completion of these aims and the mentored training in clinical and immunological
features of MS outlined in this proposal will provide me with technical training in advanced MRI pulse
programming and methods development for the spinal cord, and expanded didactic training in immunology,
sex differences in MS, neuromuscular physiology, and clinical management of MS.
 In addition to the technical expertise above, this grant will allow me to transition to independence as a
translational imaging scientist. My institution has guaranteed at least 90% protected time to the proposed
research and career development activities. My professional development will be guided by an interdisciplinary
mentorship committee led by my primary mentor Dr. Seth Smith and co-mentors Dr. John Gore and Dr.
Subramaniam Sriram. Dr. Smith is an expert in pulse programming and deployment of advanced MRI methods
in clinical populations, and Drs. Gore and Siram are renowned for their work in biomedical imaging methods
and applications and immunological factors in MS lesion recovery, respectively. I am capitalizing on
Vanderbilt’s strengths in translational imaging research and readily available clinical subjects by working with
mentors and collaborators in the Institute of Imaging Science and in clinical departments of the Vanderbilt
University Medical Center. This makes Vanderbilt a unique and stimulating environment for professional
development and completion of my proposed studies.

## Key facts

- **NIH application ID:** 10427213
- **Project number:** 5K01EB030039-03
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Kristin Poole O'Grady
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $155,578
- **Award type:** 5
- **Project period:** 2020-07-08 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10427213

## Citation

> US National Institutes of Health, RePORTER application 10427213, Development of Advanced MRI for the Thoracolumbar Spinal Cord for Clinical Application (5K01EB030039-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10427213. Licensed CC0.

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