# Preclinical and Clincial Outcomes

> **NIH NIH P50** · BAYLOR COLLEGE OF MEDICINE · 2022 · $109,493

## Abstract

The primary goal of the Preclinical & Clinical Outcomes (PCO) Core is to provide the infrastructure,
expertise and resources to support bi-directional translational efforts spanning animal and human research.
Combining the expertise of neurobehavioral tools in animal models and neuropsychiatric assessment methods
in humans will ensure the use and development of maximally relevant tasks and measures, helping to address
challenges in translational research in IDD. The PCO Core will provide investigators with a battery of validated
assays for rodents and humans, with a focus on creating a translational pipeline, as well as harmonizing
measures across studies. In addition, the PCO Core will provide access and training on the use of additional
behavioral assays that will allow IDDRC investigators to perform critical secondary or follow-up studies to
better understand the nature of any behavioral abnormality detected with a primary behavioral test battery. The
Animal Phenotyping & Preclinical Endpoints sub-core provides resources for investigators to perform
behavioral assessment across various domains in rodent models. This core also focuses on development of
robust preclinical outcome measures for assessment of potential interventions, serving as surrogate endpoints
in treatment paradigms for potential therapies. The animal phenotyping sub-core provides high quality, cost
effective behavioral assessments in rodent models, expert consultation for experimental design and data
analysis and training investigators to conduct behavior assessments independently. It also offers educational
workshops on various topics and data analysis, technical issues, trouble-shooting and development of novel
assays as preclinical outcome measures. The Human Phenotyping and Neuropsych Measures sub-core
provides neurobehavioral and neuropsychiatric assessment tools, comprising questionnaire-based methods,
structured clinical interviews, and task-based measures. Some of the innovative approaches provided by the
human phenotyping sub-core includes a novel computer vision-based technique for quantifying dynamics of
facial expression, posture, and gaze ("automated multimodal analysis"), and bio-behavioral sensing, to move
beyond traditional assessment approaches. Investigators can access consultation and guidance regarding
developing phenotyping batteries, which may involve the creation or utilization of novel approaches. They can
also access training and/or supervision in implementing and analyzing varied tasks, together with quality
assurance resources. The human phenotyping sub-core will also provide direct service in implementing
tailored phenotyping approaches for mental health conditions frequently prevalent in IDD. Finally, investigators
can access consultation regarding building animal to human models of disease state to facilitate translation.
Thus, the PCO Core's set of unique resources and broad expertise provides IDDRC Investigators a cost-
effective and flexible me...

## Key facts

- **NIH application ID:** 10427286
- **Project number:** 5P50HD103555-03
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** Rodney C Samaco
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $109,493
- **Award type:** 5
- **Project period:** 2020-07-22 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10427286

## Citation

> US National Institutes of Health, RePORTER application 10427286, Preclinical and Clincial Outcomes (5P50HD103555-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10427286. Licensed CC0.

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