# Cellular and Molecular Mechanisms of Immune Inflammatory Reactions

> **NIH NIH T32** · JOHNS HOPKINS UNIVERSITY · 2022 · $259,931

## Abstract

PROJECT SUMMARY/ABSTRACT
 This Training Grant, now entering its 36th year, provides the core source of support for a unique
interdisciplinary and interdepartmental pre-doctoral training program in Immunology at The Johns Hopkins
University School of Medicine, the Graduate Program in Immunology (GPI). The mission of the GPI is to
provide students with training in cellular, biochemical, and genetic approaches to the biology of the immune
response. We provide trainees with the ability to identify significant research questions in immunology, find
solutions to these questions, think broadly and creatively about biological problems, and communicate ideas
effectively to others. There are 36 faculty members from 10 different departments who participate in the
program and provide a broad range of training opportunities for trainees. Areas of expertise and investigation
include cancer immunology, autoimmunity, immunology of infectious disease, microbiome-related immunology,
allergy and asthma, immune cell signal transduction, immune cell gene expression and regulation,
development and maintenance of immune cells and tissues, antigen processing, presentation and recognition,
engineering of immune responses, high throughput and genome-wide assessment of immunity,
immunodeficiency, and immunology of transplantation. In these areas, the training environment is enhanced by
institutional strength in relevant areas of basic science and/or clinical medicine. Cross-fertilization between
basic research and clinical disease studies is an important aspect of the training environment. During the first
year, students take a rigorous curriculum that includes courses in fundamental immunology, graduate
immunology, macromolecular structure and analysis, genetics, molecular biology and genomics,
bioinformatics, cell structure and dynamics, pathways and regulation, responsible conduct of research, and in
addition undertake three laboratory rotations. The first year also entails a year-long immunology core
discussion course, and an introduction to immunology research course. At the end of the first year, trainees
select their thesis mentors and laboratories. The second year of training features a variety of elective courses,
a comprehensive qualifying oral exam, and the first thesis committee meeting. Professional development and
career planning is an integral part of the program. Most students publish several research papers as a result of
their thesis research. Training concludes with the presentation of a public seminar and submission of the
doctoral thesis. Progress of trainees throughout the didactic and research progress is monitored closely
through multiple mechanisms. An extensive and successful program for recruiting minority students has been
implemented. Seven predoctoral positions are projected with planned appointment of each trainee to the
training grant for two years.

## Key facts

- **NIH application ID:** 10427334
- **Project number:** 5T32AI007247-39
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Joel L Pomerantz
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $259,931
- **Award type:** 5
- **Project period:** 1982-09-01 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10427334

## Citation

> US National Institutes of Health, RePORTER application 10427334, Cellular and Molecular Mechanisms of Immune Inflammatory Reactions (5T32AI007247-39). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10427334. Licensed CC0.

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