# Data and Analytics Core

> **NIH NIH P30** · INDIANA UNIVERSITY INDIANAPOLIS · 2022 · $246,087

## Abstract

ABSTRACT (SWINE CORE)
The Swine Core of the Indiana Diabetes Research Center is a Regional/National Shared Resource Core that
has been operating and servicing researchers since 2004. The central function of the Swine Core is to reduce
barriers to the use of Ossabaw swine, a unique animal model that closely approximates human metabolic
syndrome (MetS) and progression to type 2 diabetes, with attendant long-term complications. Understanding
and therapeutic treatment of MetS and diabetes with numerous long-term health complications in humans has
been stifled by the lack of translational animal models. Experimental methods and translation to human clinical
medicine is not possible from widely used rodent and transgenic mouse models. The Swine Core will
characterize MetS and progression to type 2 diabetes and/or chemically-induced diabetes (MetS/D) and the
resulting comorbidities in Ossabaw swine. We have provided Ossabaw tissue and/or live pigs to ~160
investigators during the 15 years of the Swine Core operation. A bank of ~50 different tissues available from
each pig has enabled widespread dissemination to other investigators, providing outstanding resource sharing
and cost-effectiveness. Providing this swine resource enables testing of numerous hypotheses about the
integrated, in vivo pathogenesis and long-term complications and provides tissues for studies of cellular and
molecular mechanisms. The Swine Core is a critical interface in the translation of research from simpler animal
models (Islet & Physiology Core) to humans (Translation Core). The Swine Core is Directed by Dr. M. Sturek,
a leader in modeling human diseases in swine, and Dr. M. Alloosh serves as the Associate Director. The
Specific Aims of the Swine Core are to:
 (1). Make lean and diet-induced MetS and diabetic (MetS/D) pigs readily available, i.e. “on the shelf”.
 (2). Determine the endocrine, metabolic, and dyslipidemia indices of MetS/D to screen for optimal
phenotypes.
 (3). Provide a tissue and data bank for distribution.
These aims of the Swine Core will reduce barriers to study of this highly relevant animal model, and will
facilitate the progressive translation of research from simpler, less complex models to humans.

## Key facts

- **NIH application ID:** 10427467
- **Project number:** 5P30DK097512-08
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** AMBER L. MOSLEY
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $246,087
- **Award type:** 5
- **Project period:** 2015-07-06 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10427467

## Citation

> US National Institutes of Health, RePORTER application 10427467, Data and Analytics Core (5P30DK097512-08). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10427467. Licensed CC0.

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