# Project 3

> **NIH NIH P01** · EMORY UNIVERSITY · 2022 · $516,588

## Abstract

Project 3: Role of Cellular Senescence in long-lived plasma cell generation
Abstract:
Human long-lived plasma cells (LLPC) are important in the maintenance of protective serum
antibodies. The mechanisms of how LLPC are generated and sustained are not well elucidated.
These bone marrow resident cells are terminally differentiated, nondividing, and refractory to
apoptosis yet they are capable of secreting antibodies for a lifetime. Exodus from cell cycle and
resistance to apoptosis are major hallmarks of cellular senescence. In this application, we will
understand the role of cellular senescence in LLPC maturation transcriptionally and epigenetically
through single cell analysis. We will also dissect the unique senescence pathways that are
needed for survival; then finally we will identify the unique components of the BM microniche that
plays a role in survival and senescence.

## Key facts

- **NIH application ID:** 10428169
- **Project number:** 2P01AI125180-06
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Frances Eun-Hyung Lee
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $516,588
- **Award type:** 2
- **Project period:** 2016-06-25 → 2027-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10428169

## Citation

> US National Institutes of Health, RePORTER application 10428169, Project 3 (2P01AI125180-06). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10428169. Licensed CC0.

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