# Pro-inflammatory activation of human macrophages regulated by lncRNAs

> **NIH NIH R01** · BRIGHAM AND WOMEN'S HOSPITAL · 2022 · $723,580

## Abstract

Project Summary
Macrophage activation promotes major inflammatory disorders, including arterial diseases. Its underlying
mechanisms, however, remain obscure. The present study will establish a systems approach, involving
computational prediction analyses, multi-omics, network science, and in vitro and in vivo validation, to
discover long noncoding RNA (lncRNA)-mediated mechanisms for pro-inflammatory activation of
macrophages and arterial disease. In Specific Aim 1, we will involve omics studies of human macrophages
to identify lncRNAs and their interacting proteins and develop computational analyses to predict human
lncRNAs that regulate macrophage activation. Specific Aim 2 will examine the functionality of candidate
lncRNAs in macrophage activation in vitro and in vivo. The findings from the study will help to identify new
mechanisms for macrophage activation and may provide molecular bases for new therapies.

## Key facts

- **NIH application ID:** 10428357
- **Project number:** 5R01HL149302-04
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** Masanori Aikawa
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $723,580
- **Award type:** 5
- **Project period:** 2019-07-15 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10428357

## Citation

> US National Institutes of Health, RePORTER application 10428357, Pro-inflammatory activation of human macrophages regulated by lncRNAs (5R01HL149302-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10428357. Licensed CC0.

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