# CORE A: Participant Measures and Assessments

> **NIH NIH U19** · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · 2022 · $3,307,044

## Abstract

CORE A. PARTICIPANT MEASURES AND ASSESSMENTS
SUMMARY/ABSTRACT
During the course of the ASPREE study, a vast amount of clinical, physical function, cognitive and quality of life
data (~26 million data values) were collected from 19,114 participants by trained staff, resulting in excellent
participant retention (82% with full involvement at the end of the study), compliance (74% overall) and data
quality (99.6% accuracy). This Core will build on the operational success of ASPREE and provide methodological
and operational support for all participant-related study activity by coordinating, directing and managing the
physiological and neuropsychological assessments and questionnaires conducted routinely in ASPREE-XT
participants in both the U.S. and Australia. The Core services will ensure quality, accuracy and thoroughness of
data collection from participants through the implementation of comprehensive Standard Operating Procedures
(SOPs) and to ensure adherence to SOPs, staff in both countries will be trained prior to commencement of study
activity (see Admin Core). Data provided through the activities of Core A are the clinical nexus for all projects,
as Core A will provide clinical endpoint triggers to Core B for follow-up. The longitudinal phenotypic data provided
by Core A about ASPREE-XT participants will also be of vital importance for addressing the overall aims of this
U19 through completion of Project analyzes. Specifically, the collection of information related to cancer
screening, cancer incidence, progression, and outcomes are crucial for Project 1 (Cancer). Collection of
cognitive data, depression and dementia endpoints are essential for assessing dementia and mild cognitive
impairment outcomes in Project 2 (Dementia). Basic activities of daily living, physical function, exhaustion and
physical activity data will be collected for assessment of disability and frailty for Project 3 (Disability).
Consequently, the success of the U19 hinges upon the data that will be collected as part of this Core.
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## Key facts

- **NIH application ID:** 10428602
- **Project number:** 5U19AG062682-04
- **Recipient organization:** HENNEPIN HEALTHCARE RESEARCH INSTITUTE
- **Principal Investigator:** Robyn Lorraine Woods
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $3,307,044
- **Award type:** 5
- **Project period:** 2019-07-15 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10428602

## Citation

> US National Institutes of Health, RePORTER application 10428602, CORE A: Participant Measures and Assessments (5U19AG062682-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10428602. Licensed CC0.

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