# Microbiota-immune interactions that promote intestinal homeostasis

> **NIH NIH R01** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2022 · $606,053

## Abstract

ABSTRACT
Individuals with inflammatory bowel disease (IBD) are more likely to develop metabolic abnormalities, such as
diabetes, however little is known about the basis of this connection. Multiple studies have now shown that
changes to the composition of the microbiota are a factor in multiple diseases, including IBD and diabetes.
Moreover, the studies that have examined the composition of the microbiota within individuals with IBD or
diabetes, have identified similar changes to these resident communities. We have recently identified a mouse
model that develops worsened colitis and spontaneous obesity and insulin resistance. Both of these diseases
are reliant on the microbiota and can be rescued by a microbiota transplant, or an oral gavage of a purified
population of Clostridia. Thus, we hypothesize that the growing incidence of IBD and diabetes may be
attributable to similar defects in the microbiota and might explain the why some individuals are more prone to
develop both diseases. Based on this, we propose a series of experiments to identify a defined consortia of
Clostridia that will function to prevent disease and explore the common mechanisms, including effects of the
immune system, between IBD and metabolism that might lead to the development of these diseases. Thus, our
findings will be among the first to identify a consortia of bacteria that could be used for therapeutic
intervention/prevention of IBD and/or diabetes and allow for an in-depth mechanistic understanding of how
these protective bacteria maintain intestinal homeostasis.

## Key facts

- **NIH application ID:** 10428606
- **Project number:** 5R01AT011423-02
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** June Louise Round
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $606,053
- **Award type:** 5
- **Project period:** 2021-06-15 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10428606

## Citation

> US National Institutes of Health, RePORTER application 10428606, Microbiota-immune interactions that promote intestinal homeostasis (5R01AT011423-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10428606. Licensed CC0.

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