# POINTER-zzz: Sleep Ancillary to U.S. Study to Protect Brain Health through Lifestyle Intervention to Reduce Risk of Alzheimer's Disease - Admin

> **NIH NIH R01** · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2021 · $337,589

## Abstract

PROJECT SUMMARY
To date, greater than 30% of enrolled POINTER-zzz participants are from under-represented racial and ethnic
minority groups. A second NIA-funded ancillary study to the parent U.S. POINTER trial, POINTER-
Neurovascular (POINTER-NV), presents a unique opportunity to increase the scientific impact of POINTER-
zzz by allowing co-examination objective measures of sleep with peripheral and central measures of blood flow
in a racially and ethnically diverse group of participants. This Administrative Supplement will allow us to
increase co-participation of individuals from under-represented groups in the two ancillary studies to examine
links between lifestyle-induced changes in sleep as they relate to lifestyle-induced changes in vascular health.
Lifestyle intervention has the potential to improve sleep quality and reduce incident sleep apnea, which has
been bi-directionally linked to vascular disease in older adults. One potent health target for the POINTER
lifestyle intervention is cardiovascular health, which is disproportionately more prevalent in racial and ethnic
minority older adults. Thus, the opportunity to co-enroll additional participants who are at high risk for
cardiovascular disease into POINTER-zzz could contribute new important information to inform precision
medicine strategies targeting AD risk reduction in older adults at risk for cognitive decline and dementia.

## Key facts

- **NIH application ID:** 10429446
- **Project number:** 3R01AG064440-03S1
- **Recipient organization:** WAKE FOREST UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Laura D. Baker
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $337,589
- **Award type:** 3
- **Project period:** 2019-08-15 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10429446

## Citation

> US National Institutes of Health, RePORTER application 10429446, POINTER-zzz: Sleep Ancillary to U.S. Study to Protect Brain Health through Lifestyle Intervention to Reduce Risk of Alzheimer's Disease - Admin (3R01AG064440-03S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10429446. Licensed CC0.

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