# Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescence

> **NIH NIH R24** · HARVARD PILGRIM HEALTH CARE, INC. · 2022 · $398,594

## Abstract

Project Summary/Abstract
This application is responsive to RFA-ES-18-009: Maintain and Enrich Resource Infrastructure for
Existing Environmental Epidemiology Cohorts
Project Viva is a Boston-area cohort of 2,128 mother-child pairs from whom we have collected information on
numerous environmental exposures and health outcomes beginning in early pregnancy in 1999-2002. Our
almost two decades of data thus traverse numerous sensitive periods of the lifecourse: from gestation though
adolescence for index participants, and from pregnancy into the perimenopausal period for their mothers. Our
rich database comprises detailed information on a wealth of environmental exposures including daily air
pollution exposure estimates from satellites, local monitors, and geographic information systems; measures of
built and natural environments; biomarkers of toxicants including per- and polyfluoroalkyl substances (PFAS)
and metals; and maternal and child diet. Existing research-quality outcomes include measures of
cardiometabolic health for both mothers and children (anthropometry, body composition, blood pressure, and
biomarkers of glycemia, lipids, and adipokines); child cognition and behavior; child lung function and atopy; as
well as genetic variants and epigenetic markers.
The overall goals of the current proposal are to 1) bolster retention of Project Viva index participants through
adolescence into the young adult transition, 2) build infrastructure for future science through development and
implementation of remote data collection methods using modern technology, with a focus on environmental
exposures, and 3) enhance our data management infrastructure to facilitate data sharing with the broader
scientific community. These activities will complement our existing active grants supporting data collection and
analysis, including participation in the NIH’s Environmental Influences on Child Health Outcomes (ECHO)
Program.
The wealth of data and biosamples already available in Project Viva provide a unique opportunity to continue
to advance the research priorities of NIEHS, including examining the influence of early-life environmental
exposures, alone and in combination with other exposures and genetics, on development of chronic disease.
The proposed infrastructure activities will improve the availability of Project Viva data to the wider research
community, while simultaneously supporting our efforts to maintain this valuable resource and position our
cohort to examine novel scientific questions in the future. The enhanced infrastructure will also provide a
scalable foundation to support ongoing enrichment of the Project Viva protocols and datasets.

## Key facts

- **NIH application ID:** 10429909
- **Project number:** 5R24ES030894-03
- **Recipient organization:** HARVARD PILGRIM HEALTH CARE, INC.
- **Principal Investigator:** Emily Oken
- **Activity code:** R24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $398,594
- **Award type:** 5
- **Project period:** 2020-04-01 → 2025-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10429909

## Citation

> US National Institutes of Health, RePORTER application 10429909, Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescence (5R24ES030894-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10429909. Licensed CC0.

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