# Shared High-resolution Laser Scanning Microscope with Airyscan 2

> **NIH NIH S10** · BOSTON CHILDREN'S HOSPITAL · 2022 · $476,473

## Abstract

ABSTRACT
This grant application requests funding support for the purchase of a shared Confocal Microscope System with
a high-resolution detector to be installed in the Intellectual and Developmental Disabilities Research Center
Cellular Imaging Core, a shared microscopy facility at Boston Children’s Hospital (BCH). The requested
instrument combines enhancements in high signal-to-noise ratio, fast acquisition speed and enhanced
resolution that are not achievable by other instruments available in the area. These features will benefit a
growing number of NIH-funded research studies at BCH and Harvard Medical School that require sub-cellular
localization of proteins in fixed and living tissue at high acquisition speeds. Other research programs that need
high-resolution & high-throughput screening for translational applications will benefit immensely from this
instrument.
After installation in the Cellular Imaging Core in the Department of Neurobiology and F.M. Kirby Neurobiology
Center at BCH, this state-of-the-art microscope will benefit the 84 Harvard Medical School area laboratories
that use the core facility for basic and translational research. Primary Investigators from these labs will use the
system to study a wide variety of pressing questions regarding organelle mobility and dynamics, subcellular
architecture, protein-protein and cell-cell interactions, and the relations of these basic processes in normal
brain development, in axon regeneration and neuronal survival, and in neurodevelopmental and
neurodegenerative disorders.

## Key facts

- **NIH application ID:** 10430985
- **Project number:** 1S10OD030322-01A1
- **Recipient organization:** BOSTON CHILDREN'S HOSPITAL
- **Principal Investigator:** Chinfei Chen
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $476,473
- **Award type:** 1
- **Project period:** 2022-08-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10430985

## Citation

> US National Institutes of Health, RePORTER application 10430985, Shared High-resolution Laser Scanning Microscope with Airyscan 2 (1S10OD030322-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10430985. Licensed CC0.

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