Project Summary This proposal requests funding for a Waters Synapt XS mass spectrometer that will support biomedical research at Louisiana State University. The instrument will be placed in the LSU Department of Chemistry Mass Spectrometry Facility. The Mass Spectrometry Facility is currently the only user facility on the LSU campus where mass spectrometry-based metabolomics and other analysis to support NIH investigators. The acquisition of the proposed instrument will allow researchers at LSU to conduct metabolomics experiments for which they are currently dependent on outside facilities. This will allow NIH-funded PIs to conduct a larger portion of their experiments directly at LSU, which allows for overall more efficient research. Acquisition of a metabolomics-oriented mass spectrometer will complement the current portfolio of mass spectrometry instrumentation and provide a comprehensive platform for basic and translational research that is at the center of the biomedical research mission of the university. Acquisition of the Waters Synapt XS mass spectrometer will provide a resource that is currently available to LSU biomedical researchers and enable them to expand the scope and efficiency of their work.