# The Jackson Laboratory Knockout Mouse Production and Phenotyping Project (JAX KOMP2)

> **NIH NIH UM1** · JACKSON LABORATORY · 2021 · $160,000

## Abstract

Project Summary
The goal of the Knockout Mouse Phenotyping Project (KOMP) is to provide a comprehensive catalog of
mammalian gene function obtained through the creation of 8,500 gene knockouts and execution of a
systematic, high-throughput phenotyping pipeline. Launched in the fall of 2011, three production/phenotyping
centers including JAX were funded and assigned the task of model creation and broad-based phenotyping.
The first phase succeeded in generating and phenotyping 2,500 lines. The goals of phase 2 of The Jackson
Laboratory (JAX) KOMP program (KOMP2) during the current funding period (8/1/16 – 7/31/21) are to create
1000 knockout (KO) lines of mice and perform high-throughput phenotyping across organ systems using an
efficient and broad testing pipeline. On March 11, 2020 the World Health Organization (WHO) declared the
outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) a world-wide
pandemic. A consequence of the pandemic has been a reduction of our available personnel and services
needed to reach our original goals. The purpose of this request for a funded extension beyond the current
project period is to ensure continuity of well-developed model production pipelines, and to provide an
uninterrupted supply of mouse lines for phenotyping. We are requesting the project be extended with funds for
12 months, with a new project period end date of 07/31/2022.

## Key facts

- **NIH application ID:** 10431514
- **Project number:** 3UM1OD023222-10S3
- **Recipient organization:** JACKSON LABORATORY
- **Principal Investigator:** ROBERT E BRAUN
- **Activity code:** UM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $160,000
- **Award type:** 3
- **Project period:** 2021-07-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10431514

## Citation

> US National Institutes of Health, RePORTER application 10431514, The Jackson Laboratory Knockout Mouse Production and Phenotyping Project (JAX KOMP2) (3UM1OD023222-10S3). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10431514. Licensed CC0.

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