# Core C: Epigenetics and Quantitative Proteomics

> **NIH NIH P01** · UNIVERSITY OF PENNSYLVANIA · 2022 · $199,420

## Abstract

The Epigenomics and Quantitative Proteomics Core will provide high-end omics analyses for the Program 
Project to help identify and quantify protein expression and post-translational modifications (PTMs) on histone 
using mass spectrometry, and to provide informatics analyses from various genome-wide experiments. Expertise 
in the Core on the genomics side include analyzing data generated from next-generation sequencing and single- 
cell sequencing technologies, mapping the epigenome of various cell types and cell states including aging cells 
or cells in senescence, inquiring into the relationship of histone PTMs and transcription factor binding, and 
functionally integrating the genome, epigenome and transcriptome. On the proteomics side, the Core is well 
experienced to provide analysis of single and combinatorial histone PTMs, track cellular signaling events 
(phosphoproteomics), perform targeted metabolomics on central carbon metabolism related molecules and for 
identification of protein-protein interactions. This will include performing label-free and stable isotope labeled 
proteomics and metabolomics experiments on high-resolution Orbitrap mass spectrometers, paired with custom 
data analysis and bioinformatics. Results from all experiments will be disseminated to all Program Project team 
members to facilitate further interactions and elicit helpful suggestions for future experiments. The Core is led by 
Dr. Benjamin Garcia and Dr. Yemin Lan who together bring years of complimentary expertise, innovation and 
experience to the P01 project.

## Key facts

- **NIH application ID:** 10431998
- **Project number:** 5P01AG031862-15
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Benjamin A Garcia
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $199,420
- **Award type:** 5
- **Project period:** 2008-03-15 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10431998

## Citation

> US National Institutes of Health, RePORTER application 10431998, Core C: Epigenetics and Quantitative Proteomics (5P01AG031862-15). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10431998. Licensed CC0.

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