# Ambulatory Methods for Measuring Cognitive Change

> **NIH NIH U2C** · PENNSYLVANIA STATE UNIVERSITY, THE · 2021 · $376,303

## Abstract

Accurate and sensitive measurement of cognitive change is required to advance the
understanding of normative cognitive aging and improve the detection of the subtle
cognitive changes during preclinical stages of neurodegenerative diseases, such as
Alzheimer’s. In response to RFA-AG-18-012, we propose to develop infrastructure for
the Mobile Monitoring of Cognitive Change (M2C2) that will provide the research
community with open, flexible, and usable tools to enable scientific progress that
depends on the sensitive and accurate measurement of cognitive change. We will build
this infrastructure by accomplishing the following aims. First, we will establish rapid
iterative piloting and test development procedures that accelerate our capacity to
prototype, deploy, evaluate, and optimize candidate mobile cognitive tests to meet
psychometric, accessibility, and engagement benchmarks (Aim 1: Iterative Design &
Piloting). Second, evaluate reliability, construct validity, and longitudinal validity of
mobile cognitive testing procedures (Aim 2: Reliability & Validity) in a racially diverse
probability sample. Third, we replicate psychometric results in an independent,
nationally representative probability based sample, and create nationally representative
norms (Aim 3: Replication). And fourth, we will test our pipeline and procedures for
incorporating new measures into the mobile assessment infrastructure by evaluating
novel measures for inclusion that are nominated by investigators outside of our
immediate research team (Aim 4: Extension).

## Key facts

- **NIH application ID:** 10434331
- **Project number:** 3U2CAG060408-04S1
- **Recipient organization:** PENNSYLVANIA STATE UNIVERSITY, THE
- **Principal Investigator:** Martin J Sliwinski
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $376,303
- **Award type:** 3
- **Project period:** 2018-09-15 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10434331

## Citation

> US National Institutes of Health, RePORTER application 10434331, Ambulatory Methods for Measuring Cognitive Change (3U2CAG060408-04S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10434331. Licensed CC0.

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