# Cancer Center Support Grant

> **NIH NIH P30** · PURDUE UNIVERSITY · 2022 · $1,860,000

## Abstract

Overall
Project Summary
The Purdue University Center for Cancer Research (PCCR) was established as an NCI basic science cancer
center in 1978. As such, the PCCR's mission focuses on basic discovery - discovery that is the foundation
through which the PCCR fosters innovative cancer solutions. Notably, the PCCR not only supports basic
discovery but also facilitates discovery application and, where possible, positions discoveries for transfer to the
public domain. Purdue core strengths in engineering, veterinary medicine, nutrition science, chemistry, medicinal
chemistry, pharmacy, structural biology, and biological sciences, are coalesced by the PCCR into functional
Foundational Disciplines within a transdisciplinary environment of Research Programs, to drive collaborative
research that moves toward innovative cancer solutions. As a matrix center, PCCR leadership draws on core
capabilities through its 111 members from 21 academic departments and 7 colleges across Purdue, to organize
an infrastructure based on three Research Programs: Cell Identity and Signaling (CIS), the newly formed
Targets, Structures and Drugs (TSD), and Drug Delivery and Molecular Sensing (DDMS). The PCCR expedites
the process of discovery by managing six Shared Resources that were reorganized since the last competitive
renewal to better support future scientific needs of the PCCR: Flow Cytometry Shared Resource, Computational
Genomics Shared Resource, Biomolecular Structure Shared Resource, Life Science Mass Spectrometry Facility
Shared Resource, Biological Evaluation Shared Resource, and Transgenic and Genome Editing Facility Shared
Resource. These Shared Resources provide researchers access to state-of-the-art expertise to analyze cells,
nucleic acids and proteins, to determine detailed molecular structures that can be used to design drugs, to
evaluate targets/drugs in vivo, and to develop new animal models of cancer. These Shared Resource services
are integrated into the PCCR process of collaborative discovery to generate novel observations that lead to
innovative cancer solutions. The PCCR fosters a remarkable breath of cancer research spanning clinical
evaluations of dogs with spontaneous malignancies as an evaluative process in drug development and validation
of targets and technologies, to probing the fundamentals of molecular motion through interferometry and
determining its application to the development of innovative cancer solutions, and to the application of the
pioneering technology that is based on ionizing molecules in ambient conditions for mass spectrometry analysis
to identify cancer markers and monitor chemical reactions for continuous automated synthesis process. Finally,
the PCCR maintains the Essential Characteristics for a cancer center including exceptional Physical Space,
effective Organizational Capabilities that provide the foundation for innovative cancer research, a
Transdisciplinary Collaborative environment that facilitates fundamental discovery...

## Key facts

- **NIH application ID:** 10434749
- **Project number:** 5P30CA023168-42
- **Recipient organization:** PURDUE UNIVERSITY
- **Principal Investigator:** ANDREW D MESECAR
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,860,000
- **Award type:** 5
- **Project period:** 1998-05-08 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10434749

## Citation

> US National Institutes of Health, RePORTER application 10434749, Cancer Center Support Grant (5P30CA023168-42). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10434749. Licensed CC0.

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