# Alzheimer's Clinical Trials Consortium (ACTC)

> **NIH NIH U24** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2021 · $230,541

## Abstract

With this supplement, we request support to expand the NIH INCLUDE Trial-Ready
Cohort-Down Syndrome (TRC-DS) project, which as part of the R61 phase (cohort)
seeks to enroll 120 participants with DS, in advance of the R33 phase placebocontrolled clinical trial of an anti-amyloid therapeutic in this population. The specific
aims of the TRC-DS project include building a readiness cohort that will both inform
the design of a clinical trial as well as provide interested and eligible participants while
collecting a rich set of participant-level phenotypic data. The Institute Jérôme Lejeune
is a preeminent center in the world for clinical care of individuals with DS, including
older adults with DS-related AD. Adding this site to the ACTC-DS network for
participation in the TRC-DS project will further advance the impact and diversity of the
project and establish a strong collaboration with an outstanding research team.

## Key facts

- **NIH application ID:** 10435786
- **Project number:** 3U24AG057437-04S1
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** Paul S. Aisen
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $230,541
- **Award type:** 3
- **Project period:** 2017-12-02 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10435786

## Citation

> US National Institutes of Health, RePORTER application 10435786, Alzheimer's Clinical Trials Consortium (ACTC) (3U24AG057437-04S1). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10435786. Licensed CC0.

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