# Methods Core

> **NIH NIH P50** · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · 2022 · $1,286,604

## Abstract

ABSTRACT – METHODS CORE
The ASPIRES Methods Core (MC) brings together investigators from diverse and complementary backgrounds
to collectively address design, implementation, methodological, and technological challenges that impede
progress toward effectively reducing the youth suicide rate. Our transdisciplinary team includes experts in
study design methodology for behavioral and population interventions, predictive analytics to improve clinical
decision making, development of digital health interventions, implementation science, qualitative methods,
integration of multi-level data elements representative of patient and community health, and geospatial
modeling of environment and social structure on population health. The MC capitalizes on substantial
institutional infrastructure and intellectual capital at both The Abigail Wexner Research Institute (AWRI) at
Nationwide Children’s Hospital (NCH) and The Ohio State University (OSU), and Co-Leaders Drs. Brock,
McAlearney, and Lin have each led both specialized and multidisciplinary teams with broad impact spanning
multiple areas of health. The MC will work with ASPIRES investigators to facilitate in a pediatric population 1)
development and testing of novel and scalable interventions and research-generated resources with significant
appeal for stakeholders; 2) rapid and widespread dissemination of new, effective practices; 3) continuous
improvement of suicide prevention interventions delivered in real-world settings; 4) interdisciplinary team
science to facilitate novel and convergent solutions to intractable suicide prevention challenges; and 5) training
of students, fellows, early career, and advanced investigators from diverse backgrounds to increase the
diversity of investigators conducting cutting-edge translational suicide prevention research. Our MC provides a
methodological anchor connecting all ASPIRES projects, and our transdisciplinary team with substantial
expertise, resources, and infrastructure at both NCH and OSU will ensure that all ASPIRES projects are
conducted with scientific rigor and broadly disseminated. Creative partnerships with the Zero Suicide Institute
and the OSU CCTS Pilot Project Program augment outreach, engagement, and dissemination. Methodological
and technological advances from our MC provide innovative approaches to overcoming challenges facing
behavioral interventions for reducing the youth suicide rate. Synergistic study design elements across
ASPIRES projects provide unique opportunities to study implementation and efficacy aspects of suicide
prevention interventions across primary, specialty, and acute care. Collectively, these developments support
innovative and rigorous evaluation of ASPIRES interventions and provide the groundwork for further design
and refinement of implementation strategies necessary to scale these interventions in future studies.

## Key facts

- **NIH application ID:** 10436045
- **Project number:** 1P50MH127476-01A1
- **Recipient organization:** RESEARCH INST NATIONWIDE CHILDREN'S HOSP
- **Principal Investigator:** Guy Brock
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,286,604
- **Award type:** 1
- **Project period:** 2022-08-01 → 2027-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10436045

## Citation

> US National Institutes of Health, RePORTER application 10436045, Methods Core (1P50MH127476-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10436045. Licensed CC0.

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