# Network on Biomarker Collection and Measurement in Population Studies of Aging: 2022-2027

> **NIH NIH R24** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $405,629

## Abstract

The goal of this renewal will be to maintain and further develop an interdisciplinary network of scientists
dedicated to improving measurement of biological risk for late life health outcomes to be fielded in large
representative population samples. Biological risk is defined by indicators of genomic and physiological state
that increase the probability of disease, disability, loss of physical or cognitive functioning, or death. The
network will continue to focus on assessing, validating, and harmonizing biological risk measurement in studies
of populations; expanding geroscience measures available for use in populations; and developing
methodological approaches for including complex dimensions of health in analytic models. This current project
will build on the extensive progress made building an initial interdisciplinary research network (funded by NIA
from 2009 to 2015) and the prior iteration of this network (2016-2021). Over the last 5 years dissemination of
harmonizing information and harmonized data was a major product of the network. The network disseminated
protocols for collection methods, assay methods, quality control methods, harmonization methods, basic
training on relevant topics of sample collection and preparation, and analytic methods. The network promoted
valid interdisciplinary and international research on the associations of social, biological, economic, and
psychological factors and the biological paths leading to health outcomes common in older age in large
community and national population surveys.
 In addition to maintaining the harmonization and training efforts made during the last funding period, the
network will focus on at least 4 new activities for the 2022-2027 period. The areas of increased emphasis
include: 1) harmonization of molecular (e.g. epigenetic and RNA) biomarkers of health and aging over the life
course, 2) exploring emerging geroscience biomarkers for potential application in large representative studies
of aging, including biomarkers of Alzheimer's disease and related dementias (ADRD), 3) examination of
biomarkers of environmental exposures (e.g. pollution, toxicants, severe weather), and 4) increasing
representation of biosocial data and scholars from underrepresented populations. To accomplish these goals
network efforts will include designing and carrying out a series of general and topic-specific meetings including
annual meetings of the network and yearly specialized interactive workshops, as well as regular webinars and
calls with theme and working subgroups, consulting with individual studies to develop plans for data
collection and processing, supporting pilot projects to harmonize and develop measurement, dissemination of
white papers to share information about emerging biomarkers, and supporting travel for scholars from
underrepresented populations. As evidenced by the growth and utilization of this network over the last funding
period, biological data collection and measurement is a growin...

## Key facts

- **NIH application ID:** 10436475
- **Project number:** 2R24AG054365-06
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** EILEEN M CRIMMINS
- **Activity code:** R24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $405,629
- **Award type:** 2
- **Project period:** 2016-09-15 → 2027-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10436475

## Citation

> US National Institutes of Health, RePORTER application 10436475, Network on Biomarker Collection and Measurement in Population Studies of Aging: 2022-2027 (2R24AG054365-06). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10436475. Licensed CC0.

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