# Supplement to Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling

> **NIH NIH R35** · UNIVERSITY OF DELAWARE · 2021 · $48,234

## Abstract

This supplement to R35 GM131816 is focused on the development of a series of new deaminative
cross-couplings and the training of graduate student Bria Garcia, in line with the goals of PA-21-
071. The scientific goals of this supplement are to develop (1) reductive cross-electrophile
couplings of alkylpyridinium salts and (hetero)aryl chlorides, and (2) cascade cyclizations of
alkylpyridinium salts tethered to alkenes to deliver a range of cyclic products. Both these reactions
transform readily available starting materials into valuable motifs found in bioactive molecules.
This research will hone Ms. Garcia’s expertise in catalytic method development. It will also greatly
enhance her research capabilities by giving her experiences in high-throughput experimentation
(HTE), collaborative interactions and insight with medicinal chemists at Pfizer, Inc., and
proficiency in developing stereoselective transformations. This supplement proposal also includes
a mentoring plan, including participation in UD’s Chemistry-Biology Interface program, multiple
courses and workshops, teaching and mentoring experience, and professional networking
opportunities, to maximize Ms. Garcia’s training and future success.

## Key facts

- **NIH application ID:** 10436560
- **Project number:** 3R35GM131816-03S1
- **Recipient organization:** UNIVERSITY OF DELAWARE
- **Principal Investigator:** Mary P Watson
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $48,234
- **Award type:** 3
- **Project period:** 2019-06-01 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10436560

## Citation

> US National Institutes of Health, RePORTER application 10436560, Supplement to Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling (3R35GM131816-03S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10436560. Licensed CC0.

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