# Molecular Repair of Diabetic Mesenchymal Stem Cells (dMSC) for Peripheral Arterial Disease

> **NIH VA I01** · VETERANS HEALTH ADMINISTRATION · 2022 · —

## Abstract

Diabetes and peripheral arterial disease (PAD) disproportionately affect our nation's Veterans. Diabetic
patients have limited collateralization and regenerative capacity in their tissues. Diabetic patients with
peripheral arterial disease have severe ischemic complications and are at grave risk of major amputation.
Reversing tissue ischemia by surgical revascularization prevents amputations, but many patients with diabetes
and peripheral arterial disease are not fully treatable by surgical revascularization. Regenerative cell-based
therapies may enable a full step forward in re-establishing or regenerating the vascular supply of the leg to
prevent amputations. We have identified a unique intracellular signaling defect in diabetic mesenchymal stem
cells that can be favorably modified to improve these cells. This proposal will test the effectiveness, durability
and then mechanism by which this approach works under diabetic conditions using relevant in vitro and in vivo
models. Positive results will be used to translate these methods to Veterans with diabetes and PAD.

## Key facts

- **NIH application ID:** 10436770
- **Project number:** 5I01BX004707-03
- **Recipient organization:** VETERANS HEALTH ADMINISTRATION
- **Principal Investigator:** LUKE Packard BREWSTER
- **Activity code:** I01 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2022
- **Award amount:** —
- **Award type:** 5
- **Project period:** 2020-01-01 → 2023-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10436770

## Citation

> US National Institutes of Health, RePORTER application 10436770, Molecular Repair of Diabetic Mesenchymal Stem Cells (dMSC) for Peripheral Arterial Disease (5I01BX004707-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10436770. Licensed CC0.

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