# Interdisciplinary Research Network on Biologically Active Tau Aggregate Polymorphs from Alzheimer's Disease and Related Dementias

> **NIH NIH U24** · UNIVERSITY OF TEXAS MED BR GALVESTON · 2022 · $1,544,885

## Abstract

PROJECT SUMMARY
Tau aggregation is a shared pathology of Alzheimer's disease and related dementias known as tauopathies.
Because each disorder develops a unique combination of aggregate polymorphisms and co-morbidities that may
influence the course and severity of disease, elucidating the relationship between tau aggregate structure and
biological activity has become a high priority in the field. Advances to date have been limited, however, by the
lack of rigorously standardized aggregate preparations from each form of tauopathy and by the absence of tools
needed to selectively detect their presence in biological models and clinical specimens. The proposed
Interdisciplinary Research Network on Biologically Active Tau Aggregate Polymorphs seeks to address this need
by (1) isolating a full range of biologically active tau aggregates from authentic Alzheimer's disease, Corticobasal
Degeneration, Progressive Supranuclear Palsy, and Pick's disease brain tissue, (2) establishing their structures
through biophysical analysis, (3) developing probe sets for their selective detection, and (4) disseminating
reliably vetted samples and lab-ready protocols for their handling and storage to the broader research
community. In accomplishing these goals, the network will support research into the molecular basis of tauopathy
pathogenesis and catalyze efforts toward creating novel diagnostic and therapeutic strategies specifically tailored
against toxic tau aggregate polymorphs.

## Key facts

- **NIH application ID:** 10436894
- **Project number:** 5U24AG072458-02
- **Recipient organization:** UNIVERSITY OF TEXAS MED BR GALVESTON
- **Principal Investigator:** DAVID EISENBERG
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,544,885
- **Award type:** 5
- **Project period:** 2021-07-01 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10436894

## Citation

> US National Institutes of Health, RePORTER application 10436894, Interdisciplinary Research Network on Biologically Active Tau Aggregate Polymorphs from Alzheimer's Disease and Related Dementias (5U24AG072458-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10436894. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*