PROJECT SUMMARY/ABSTRACT – Administrative Core The mission of the Center for Chronic Disease Reduction and Equity Promotion Across Minnesota (C2DREAM) is to support and translate innovative, transdisciplinary research that intervenes on and addresses racism at multiple levels as a fundamental cause of disparities. Specifically, C2DREAM targets disparities in cardiovascular disease (CVD), hypertension, and obesity, hereafter referred to as CVD and RCC (related chronic conditions), among Black, Indigenous, and people of color (BIPOC) across a diverse rural-urban Minnesota region. The C2DREAM Administrative (AD) Core will provide strong, equity-guided governance, administrative, and communications infrastructure; coordinated data collection of innovative measures of racism at multiple levels and shared implementation processes; innovative research assessing the multifactorial relationship between structural and interpersonal, intervention efficacy, and chronic disease- related behavior change; innovative programming that connects trainees, researchers, community stakeholders, and policy makers in knowledge sharing and application for change; and equity-oriented rigorous evaluation to assure center impact. The AD Core’s success will be reflected in the Center’s launch and sustenance, and seamless integration of all Core activities and research projects. We build on extensive institutional infrastructure, professional and community relationships, compelling health equity research, and vibrant intellectual and translational activities across the region. The AD Core embraces a shared leadership model—reflected throughout the Center—underscoring our belief that health equity will be achieved in Minnesota only through collective action drawn from strong inter-institutional regional collaboration and multiple sources of knowledge. Buttressed by strong institutional foundations and enhanced regional networks, the AD Core will foster C2DREAM’s regional impact in several important ways: (a) Provide the infrastructure, governance, and leadership to ensure that all C2DREAM components operate efficiently across the region. (b) Leverage innovative means to assess racism at multiple levels. (c) Augment activities offered by other Cores to creatively support the productivity of early-stage researchers. (d) Apply robust equity-grounded multimodal evaluation methods to inform flexible adaptation of our approaches and ensure we achieve the Center’s goals, and promote exportation of lessons on the most effective elements for use by other P50 centers.