The overall goal of the Southern California Center for Chronic Health Disparities in Latino Families and Children (SCC-CHDLFC) is to establish a regional coalition of academic, clinical, government and community stakeholders to address the co-occurring disparities in obesity, type 2 diabetes, non-alcoholic fatty liver disease, and dyslipidemia that are disproportionally affecting Latinos in our region with a focus on addressing early life determinants and family-based strategies for prevention and treatment. The SCC-CHDLFC is a comprehensive and inclusive regional coalition of individuals and organizations that builds on existing collaborations and leverages numerous resources. This coalition will provide the necessary expertise and support to advance understanding, prevention, and treatment of the multilevel behavioral, nutritional, biological, inter-personal, social, and environmental factors that contribute to vulnerabilities for these chronic conditions among Latinos. The overall goal of the Administrative Core is to ensure the success, scientific rigor, and regional and societal impact of the Center. The Core will be led by Drs. Goran (CHLA) and Baezconde-Garbanati (USC) who provide complementary expertise in clinical/translational research in Latinos and community engagement and have a track record of working together leading mulit-investigator Centers related to minority health and health disparities. The Core will be responsible for structuring, initiating, maintaining, and coordinating all Center activities to ensure that goals are met, including scientific progress, developing a diverse pool of young investigators, program evaluation, and influencing lasting changes at the community and system levels, through 3 Specific Aims. Aim 1 is to provide overall leadership and vision as well as scientific, fiscal, and administrative oversight. This oversight will ensure scientific rigor and maximize interaction between Center cores, research projects, and pilot studies to ensure integrated efforts in research, training, career development, and community engagement are met, that team science strategies are utilized, and that trans-disciplinary opportunities are maximized. Aim 2 is to ensure data quality and harmonization by providing high-level methodological expertise to the projects and pilot studies through a Methods and Data Sub-Core. By leveraging existing Research Cores, we will provide efficient and rigorous Center-wide expertise in biostatistics, data management and and assessment of social determinants of health, dietary intake, and geospatial factors. This will accelerate and promote transdisciplinary research, integration, and synergy across our Center and the P50 program. Aim 3 is to conduct ongoing program evaluation to guide the progress and impact of the Center, with a feedback loop for Center improvements to ensure the Center stays on track and meets its objectives. Ongoing and systematic evaluation will determine progress towards...