# ACHIEVE P3 - CHD

> **NIH NIH P50** · WAYNE STATE UNIVERSITY · 2021 · $871,895

## Abstract

ABSTRACT
The substantial improvement in lifespan and health span in the United States, attributable to improvements in
awareness, detection and treatment of risk factors have not translated into Black individuals. Life expectancy
among Black males remains recalcitrantly low and comparable to the developing world. Socio-economic
status, education, neighborhood, built environment, community context and behavioral factors or social
determinants of health (SDoH) account for ~80% of variance in health outcomes and cluster geographically.
Strategies to address health inequities in Black individuals must acknowledge and address SDoH. Precision
health technologies, access to care coordination and guidance on lifestyle, diet and pharmacotherapy have
traditionally been the prerogative of the privileged, but offer value, by virtue of their accuracy and co-benefits of
engagement, education and empowerment. The overall hypothesis of PROJECT 3 is that a visionary free
precision medicine approach to identify “at-risk” Blacks. and linkage to care using a pragmatic reimbursable
HUB-facilitated, community health worker (CHW) led, personalized, adaptable approach to lifestyle and life
circumstance (PAL2) intervention, will improve the triple goal of optimal blood pressure, lipids and glucose
targets. PAL2 will incorporate proven interventions including CHW care coordination, motivational interviewing,
lifestyle coaching, home blood pressure monitoring and importantly will be tunable to address high risk
patients (CAC≥100) with a nurse-dietician-pharmacist. We will partner with the Cuyahoga Metropolitan
Housing Authority (CMHA), one of the nation’s largest subsidized housing programs and Better Health
Partnerships (BHP), a Cleveland based non-profit, that offers a CHW-HUB model of care. Utilizing a Practical
Robust Implementation and Sustainability Model (PRISM) framework to address RE-AIM domains (Reach x
Efficacy: Adoption, Implementation, Maintenance) and contextual factors, our multi-disciplinary team will test
the benefits of a tunable PAL2 intervention to achieve guideline driven targets while exploring contextual
factors that may determine the success of our intervention.

## Key facts

- **NIH application ID:** 10437398
- **Project number:** 1P50MD017351-01
- **Recipient organization:** WAYNE STATE UNIVERSITY
- **Principal Investigator:** Sanjay Rajagopalan
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $871,895
- **Award type:** 1
- **Project period:** 2021-09-24 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10437398

## Citation

> US National Institutes of Health, RePORTER application 10437398, ACHIEVE P3 - CHD (1P50MD017351-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10437398. Licensed CC0.

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