# Arousal and Timekeeping in a Mouse Model of Parkinsonism

> **NIH NIH R15** · UTAH STATE UNIVERSITY · 2022 · $437,997

## Abstract

PROJECT SUMMARY / ABSTRACT
Movement disorders, such as Parkinson’s Disease (PD) and Huntington’s Disease, are
characterized by drastic impairments in planning and executing movement, as well as cognitive
deficits, some of which stem from deficits in estimating durations. Estimation and reproduction
of durations in the seconds-to-minutes range are critical for fundamental processes such as
associative learning, planned motor responses and decision-making. This project will explore
neurobiological mechanisms involved in the estimation and reproduction of durations to
evaluate timed motor response deficits in mouse models of PD. We will investigate the role of
arousal, and the involvement of a novel neurotransmitter, orexin, in alterations of timed
response selection using a newly developed model of timed response selection deficits in PD.
We will also evaluate pharmacological approaches to rescue motor timing deficits. The project
will enhance our understanding of neuronal processes involved in cognitive and motor control
deficits in movement disorders, and will help develop new treatment strategies in animal
models, with possible subsequent impact on clinical treatments.

## Key facts

- **NIH application ID:** 10437525
- **Project number:** 1R15NS123824-01A1
- **Recipient organization:** UTAH STATE UNIVERSITY
- **Principal Investigator:** CATALIN V. BUHUSI
- **Activity code:** R15 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $437,997
- **Award type:** 1
- **Project period:** 2022-04-01 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10437525

## Citation

> US National Institutes of Health, RePORTER application 10437525, Arousal and Timekeeping in a Mouse Model of Parkinsonism (1R15NS123824-01A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10437525. Licensed CC0.

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