Project Summary/Abstract: The ANTHC NARCH XII Administrative Core is designed to ensure the success of the overall ANTHC NARCH XII program and meet the needs of ANTHC. The overall goal of the ANTHC NARCH XII program is to build on previous work by ANTHC NARCH and other programs, existing strengths and partnerships, and identified needs to continue to increase the capacity of Alaska Native people and tribal health organizations to conduct tribally-driven research in pursuit of ANTHC’s vision that Alaska Native people are the healthiest people in the world. The specific aims for the overall NARCH are to: 1) increase the capacity of Alaska Native people and tribal health organizations to design and conduct health research while including indigenous ways of knowing; 2) conduct tribally-driven health research focused on improving the health of Alaska Native people and reducing health disparities; and 3) expand on existing ANTHC partnerships. The ANTHC NARCH XII program consists of multiple components. Dr. Ferucci is responsible for overseeing the center as PI, with the assistance of Co-Investigator Dr. Thomas. The specific aims of the Administrative Core are to: 1) provide administrative, ethical, regulatory, and fiscal guidance and oversight for each of the funded capacity building and research projects; 2) oversee researcher and mentor development, with a focus on structured mentor/mentee relationships and collaboration with existing career development and pilot grant programs; 3) improve the research consultation and research review processes by ANTHC and regional tribal health organization partners by supporting existing research consultation and review committees with their capacity building and educational needs; and 4) support the evaluation plans for each project and for the center as a whole. The Administrative Core will enhance the ability of the overall ANTHC NARCH XII program to fulfill its specific aims, including successful completion and evaluation of the capacity building and research projects. The expected outcome is a continued improvement in ANTHC’s capacity to conduct tribally- driven health research, ultimately leading to improved health, well-being, and resilience of the Alaska Native population.