Project Summary/Abstract This proposal is for continued NIH support 0f graduate student training in the Interdepartmental Neuroscience Program (INP) of Yale University. The INP is Yale’s university-wide interdepartmental doctoral program, currently in its 32nd year. Currently six students are supported in years 1 and 2 (a total of 12 students annually) by the INP Jointly Sponsored Predoctoral Training Program in Neuroscience (JSPTPN). As a reflection of the notable increases in applications from TG-eligible students as well as the increase in Yale neuroscience faculty, tuition and stipend support is requested for an additional seventh student for each year (a total of 14 students). The faculty of the INP’s T32 JSPTPN consists of 83 neuroscientists from the Arts and Sciences (FAS) and the Yale Medical School (YMS). For the 2019/2020 academic year there are 82 predoctoral (NOT including our 22 MD-PhD students working full time in lab) graduate students, of which 50 are TG-eligible. The INP is directed by Charles Greer and Haig Keshishian and supervised by an executive committee representing a cross-section of INP faculty and graduate student representatives. Greer and Keshishian serve as the Program Directors for the INP’s T32 Training Program. The INP receives strong university support, including salaried administrators, office space, 8 full fellowships with tuition, and stipend supplementation. The doctoral program undergoes scheduled reviews by the Graduate School as well as our own anonymous reviews from students and faculty and an outside advisory committee. The INP is part of Biological and Biomedical Sciences (BBS) umbrella program, but students are admitted directly into the INP through a neuroscience admissions committee. Upon affiliating with the INP the students remain in the interdepartmental program through their graduation. On average over the past funding cycle, 171 US/permanent resident students have applied annually, with 32% offered admission, for an entering class averaging 11 students (2019/2020 class: 17 US students). The INP is actively involved in educating students from underrepresented groups. Since 2015 20% (2019/2020 = 41%!) of the US/permanent resident neuroscience students in the program were from these groups. Students are supervised by the Co-Directors, an executive committee, and through longitudinal mentoring beginning with matriculation. All INP students take four core graduate classes in neuroscience, quantitative skills and bioethics, two advanced course electives, and two 1st year research rotations. They attend invited seminars, research in progress talks, an annual retreat and the Society for Neuroscience meeting at the program’s expense. In the 2nd year the students select a doctoral adviser from the pool of participating faculty. They also take the doctoral qualifier examination, which has tutorial, written, and oral components. The students advance to candidacy for the PhD upon defending a prospectus in the...