NARCH Overall Abstract The overall goal of the Center is to support health research projects that benefit Tribal Members, develop relationships to enhance tribal governance and partnerships in health research, conduct research that honors Tribal sovereignty, and promote a cadre of AI/AN researchers in health disparities research. The University of Arizona and ITCA missions and activities differ in deliberate ways and the AIRCH unites our Tribally governed 501(c) 3 and our research intensive institution to provide a collaborative service to our 21 member Arizona Tribes, and the Arizona AIAN population. The ITCA and the University of Arizona are fully committed to the continuing success and impact of AIRCH and are prepared to provide our full institutional resources. Together we aim to advance the impact of health research by leveraging the university system’s medical center and health and educational programs to create more effective pathways to benefit our Tribal constituents and to support Native students and faculty. The AIRCH XI is comprised of one core (Administration) and four projects to support the following NARCH objectives: • To support research opportunities for the enhancement of students, faculty, and researchers concerned with AI/AN health; • To build capacity/infrastructure within AI/AN communities to ensure sustainability of biomedical research and the ability to address pertinent health issues within Tribal communities; • To disseminate effective individual, community, and population-level interventions to reduce and encourage the elimination of health disparities; and • To support research that will reduce health disparities in health and social consequences among AI/AN.