PROJECT SUMMARY This project was developed in partnership with and supported by IHC leaders and the Tribal Council. It will actively use a community-engaged research approach, which helps ensure IHC- centric leadership and direction. As such, there is high probability that study findings will be relevant to IHC clinical and public health practice, allowing for rapid effective dissemination, and sustainability. This research is significant in that it addresses the extremely low cervical cancer screening rates among AI/AN women and the low HPV vaccination rates in adolescents. The proposed multi-level intervention in low-resource health care settings in Southern California has potential to provide scalable and sustainable solutions for cervical cancer prevention and HPV- related malignancies that could be adopted. Page 1