# Cancer Biology (CB) Program

> **NIH NIH P30** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $57,370

## Abstract

PROJECT SUMMARY/ABSTRACT (CANCER BIOLOGY)
Members of the Cancer Biology (CB) Program are engaged in basic and translational studies focused on
cancer-associated alterations in cell and tissue biology that underlie tumor initiation, expansion, and
progression. CB program members work on one or more of three interrelated themes (stem cells, tumor
microenvironment, and signaling), and their research accomplishments have led to advances impacting on the
diagnosis, prevention, and treatment of cancer. The CB Program comprises 64 members from 29 departments
and four schools at the University of Michigan. Total annual direct research support is $21.7M, with $7.1M
(33%) from the NCI and $6.6M (30%) from other NIH support, with a total of $16.4M (75%) representing
peer-reviewed funding. Investigators are involved in intra- and inter-programmatic interactions and actively
collaborate with UMCCC researchers within the Basic Science, Translational and Clinical Research, and
Cancer Control and Population Sciences Programs. During the project period, CB Program members
authored a total of 1038 cancer-relevant publications, of which 22% were intra-programmatic and 42% were
inter-programmatic. The shared research interests of program members are reflected in the program’s overall
scientific aims: 1) elucidate the role of stem cells and their niches in cancer, 2) determine functions of the
tumor microenvironment in cancer, and 3) characterize deregulated signaling changes during tumorigenesis.
Through focused effort centered on shared scientific interests and a commitment to mentorship, CB program
members have generated a body of knowledge that has yielded a deeper understanding of the cellular and
extracellular factors governing tumor behavior. The ultimate goal of the CB Program is to apply new insights
towards improving cancer detection, prevention, and treatment through robust intra- and inter-programmatic
interactions and collaborations, both at the University of Michigan and other institutions.
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## Key facts

- **NIH application ID:** 10438628
- **Project number:** 5P30CA046592-33
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** ANDRZEJ A. DLUGOSZ
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $57,370
- **Award type:** 5
- **Project period:** 1997-06-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10438628

## Citation

> US National Institutes of Health, RePORTER application 10438628, Cancer Biology (CB) Program (5P30CA046592-33). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10438628. Licensed CC0.

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