# Cancer Genetics (CG) Program

> **NIH NIH P30** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $67,505

## Abstract

PROJECT SUMMARY/ABSTRACT (CANCER GENETICS)
The Cancer Genetics (CG) Program is a group of interdisciplinary researchers who seek to advance
knowledge of the genetic and epigenetic mechanisms that underlie cancer development and progression.
Investigators in the CG Program perform basic and translational research aimed at understanding the origins
and nature of cancer, thereby leading to novel preventive and diagnostic approaches as well as the improved
clinical management of cancer patients. To reach these goals, the CG Program is organized as a diverse,
interdisciplinary research group with 35 members from 19 departments within three U-M schools/colleges (i.e.,
Medical School; School of Public Health, College of Literature, Science and the Arts). Currently, annual direct
research support totals $11.1M in cancer grant funding with $3.5M (31%) from NCI, $3.9M (35%) from other
NIH grants, and $2.6M (24%) from additional peer-reviewed funding. CG members are actively involved in
intra- and inter-programmatic interactions with researchers in the Basic Science, Clinical Research, and
Cancer Control and Population Sciences Programs. Members focus their efforts on one or more of four
interrelated themes, including oncogene and tumor suppressor gene networks, transcription factor/chromatin
modification complexes, genomic instability, and the development of clinically relevant, genetically-engineered
animal models. With combined effort, the Program has generated important insights in cancer development,
diagnosis, treatment and prevention, having authored a total of almost 700 cancer-relevant publications during
the project period, of which 14% were intra-programmatic and 52% were inter-programmatic. In the current
proposal, three scientific aims are detailed: 1) elucidate the genetic and epigenetic mechanisms of cancer
development and progression, 2) utilize novel animal model systems for characterizing the impact of key
genetic alterations found in human cancers, and 3) advance approaches for translating new insights into
effective strategies for cancer prevention, early diagnosis, and treatment. By focusing efforts on shared
scientific interest across UMCCC programs, in tandem with a commitment to training as well as mentorship,
CG Program members have generated a cohesive body of knowledge that has yielded novel and important
insights into the genetic and epigenetic mechanisms underlying cancer initiation and progression. In keeping
with these accomplishments, the Program seeks to further advance the development of new strategies for
preventing, diagnosing and treating cancer.!

## Key facts

- **NIH application ID:** 10438629
- **Project number:** 5P30CA046592-33
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** DAVID George BEER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $67,505
- **Award type:** 5
- **Project period:** 1997-06-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10438629

## Citation

> US National Institutes of Health, RePORTER application 10438629, Cancer Genetics (CG) Program (5P30CA046592-33). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10438629. Licensed CC0.

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