# CORE B: Biophysiologic Modeling Core

> **NIH NIH P01** · NORTHWESTERN UNIVERSITY · 2022 · $159,747

## Abstract

CORE SUMMARY
 The Biophysiologic Modeling Core will have the following primary components: 1) Biophysiologic
Data Warehouse (BDW), 2) Biophysiologic Modeling Center (BMC), and 3) Mechanistic Data
Warehouse (MDW). The Biophysiologic Data Warehouse will be a database and file repository that
provides high-level physiological data coupled with clinical and research data, and will serve as the central
data hub for the PPG. The Biophysiologic Modeling Center will contain computational hardware for desktop
and high-fidelity parallel computing, and computational software for physics-based computations of esophageal
physiology under normal and abnormal conditions. The center will al so house physics-based software for
novel in-vivo/in-silico hybrid diagnostic tools based on FLIP and manometry. The primary development
work of these mathematical modeling tools will be done in this CORE. In addition, user support to apply these
tools to tasks in Project 3 will be provided in this CORE. The goal is the translation of computational
biophysics models into clinical practice. To that end, BMC will provide technical support for the
following activities: i) software development, ii) fundamental research of organ/system physiology, iii)
patient specific analysis and diagnostics, and iv) design and development of next generation diagnostic
tools (e. g. FLIP, manometry).
 Esophageal physiology simulations, performed using the software, will generate data providing insights
into the mechanism underlying the normal and abnormal function of the esophagus. These will be termed
Mechanistic Data, which will be housed within the MDW. These data will be coupled to physiological and clinical
data from the BDW. The mechanistic data will be mapped onto The Chicago Classification of esophageal motility
disorders. These data will be important to the development of the Virtual Disease Landscape (VDL) in Project 3.

## Key facts

- **NIH application ID:** 10439749
- **Project number:** 5P01DK117824-05
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** Neelesh A. Patankar
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $159,747
- **Award type:** 5
- **Project period:** 2018-07-15 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10439749

## Citation

> US National Institutes of Health, RePORTER application 10439749, CORE B: Biophysiologic Modeling Core (5P01DK117824-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10439749. Licensed CC0.

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