# Nurses Health Study 3: A multiple exposure environmental epidemiology cohort of young adults

> **NIH NIH R24** · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2021 · $59,015

## Abstract

PROJECT SUMMARY OF PARENT PROJECT (R24ES028521)
This is an R24 application to support the infrastructure of our environmental epidemiology cohort,
Nurses’ Health Study 3 (NHS3), an open, prospective, web-based cohort (www.nhs3.org).
Participants are residence of the United States and Canada born after 1965. Most of the female
participants (89%) have enrolled before menopause and 41% of female participants and 62% ofmale
participants have no prior pregnancy history. In this innovative web-based study, we have been
collecting detailed information on personal characteristics and potential disease risk factors every 6
months, including diet, physical activity, psychosocial factors, and a wide variety of occupational
and environmental exposures. Data collection has focused on current exposures, as well as those
experienced during adolescence, prior to first pregnancy, and during pregnancy.Discoveries made in
NHS3 will build on the knowledge and experience gained from earlier cohorts on the impacts of
the environment on chronic disease risk but takes advantage of modern technology to collect novel
prospective data during important windows of exposure across the life course. The NHS3
investigators have substantial experience in environmental epidemiology,exposure assessment, and
Big Data analytics, as well as in managing and maintaining large prospective cohort studies. This
cohort provides a unique opportunity to address key outstanding questions in environmental
epidemiology, by collecting highly detailed information on multiple environmental exposures at
key points in the life course.
The R24 supports infrastructure activities in the expanded NHS3 cohort thatmaximize the existing
resources and broaden the current scope of research, to allow the investigation of multiple
environmental exposures. We will focus our efforts in three main areas: 1) the expansion of study
operations and maximization of existing resources, 2) the collection of environmental exposure
samples, and 3) expansion of web-based mobile technologies and assessment of spatial uncertainty
and measurement error. We have partnered with U01HL145386 to collect biologic samples (blood,
urine, stool) concurrently with the environment exposure samples. This administrative supplement will
allow us to prepare cost-effective lab-ready vials of both biologic and environmental specimens at the
time of collection.

## Key facts

- **NIH application ID:** 10440077
- **Project number:** 3R24ES028521-04S1
- **Recipient organization:** HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH
- **Principal Investigator:** Jorge Eduardo Chavarro
- **Activity code:** R24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $59,015
- **Award type:** 3
- **Project period:** 2021-09-10 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10440077

## Citation

> US National Institutes of Health, RePORTER application 10440077, Nurses Health Study 3: A multiple exposure environmental epidemiology cohort of young adults (3R24ES028521-04S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10440077. Licensed CC0.

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