# OGT as a dosage sensor

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $415,928

## Abstract

Project Summary
Epigenetic regulators often lie downstream of signaling pathways that culminate in post-translational
modifications, which affect their activity and ensure appropriate transcriptional responses to developmental and
environmental cues. Our preliminary studies indicate that an interaction between epigenetic regulator, TET3,
and an X-linked, post-translational modification enzyme, OGT, may be central in detecting X chromosome
dosage and poising cells for X-inactivation. We propose to investigate the role of the TET3-OGT interaction in
regulation of X chromosome inactivation, to obtain molecular insight into how cells count X chromosomes.

## Key facts

- **NIH application ID:** 10440360
- **Project number:** 5R01GM128431-04
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** ALMA L BURLINGAME
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $415,928
- **Award type:** 5
- **Project period:** 2019-09-15 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10440360

## Citation

> US National Institutes of Health, RePORTER application 10440360, OGT as a dosage sensor (5R01GM128431-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10440360. Licensed CC0.

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