# Large Scale T Cell Epitope Discovery: Proteome-wide characterization of T cell epitopes from  Mycobacterium tuberculosis in vaccination and active infection

> **NIH NIH N01** · LA JOLLA INSTITUTE FOR IMMUNOLOGY · 2021 · $918,786

## Abstract

This contract supports highly interactive, multi-disciplinary teams, whose research efforts are focused on large-scale discovery of T cell immune epitopes, validation of these epitopes, and defining their role in immune protection or immune-mediated pathogenesis in humans. Milestones include: 1) epitope identification; 2) in vitro epitope validation studies with primary human T cells to demonstrate the immunogenicity/antigenicity or diagnostic potential of all newly defined T cell epitopes shown to bind to classical or non-classical MHC molecules; and 3) submission of all epitope information and computer software to the Immune Epitope Database and Analysis Resource to facilitate access and use of the data and tools by the broader research community.

## Key facts

- **NIH application ID:** 10441009
- **Project number:** 75N93019C00067-P00004-9999-1
- **Recipient organization:** LA JOLLA INSTITUTE FOR IMMUNOLOGY
- **Principal Investigator:** Bjoern Peters
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $918,786
- **Award type:** —
- **Project period:** 2019-09-30 → 2022-09-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10441009

## Citation

> US National Institutes of Health, RePORTER application 10441009, Large Scale T Cell Epitope Discovery: Proteome-wide characterization of T cell epitopes from  Mycobacterium tuberculosis in vaccination and active infection (75N93019C00067-P00004-9999-1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10441009. Licensed CC0.

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