# Comp C Spina Bifida Urologic Protocol at Vanderbilt Children's Hospital

> **NIH ALLCDC U01** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2022 · $25,000

## Abstract

PROJECT SUMMARY
Advances in medical care have increased longevity for babies born with spina bifida, the most common
permanently disabling birth defect in the United States. The main goals of the urologist participating in the care
or patients with spina bifida are: 1) to preserve normal renal function and 2) to ensure adequate bladder
continence for enhancing self-esteem and independence. Despite these common goals, practice patterns vary,
and best practices are not well defined. The Urologic Management to Preserve Initial Renal Function Protocol
(UMPIRE) has been designed to evaluate outcomes on a standardized urologic protocol from the neonatal period
to 10 years of age. The Spina Bifida Program at Monroe Carell Jr. Children's Hospital at Vanderbilt (MCJCHV)
evaluates approximately 20 newborns with spina bifida each year. The pediatric urology division at MCJCHV
has set the following goals for this study: 1) to approach each eligible patient in our program for enrollment, 2)
to contribute longitudinal data on diagnostic studies and interventions as specified by the protocol, and 3) to
evaluate data from UMPIRE to answer hypothesis-driven questions specifically about clinical predictors for
hostile videourodynamics and decreased renal function. The PI along with the clinical research coordinator will
ensure quality control of data submitted to the CDC. The PI has a demonstrated record of productive research
UMPIRE. Published results from this study will help to inform best practice clinical guidelines for urologic
management in the child with spina bifida

## Key facts

- **NIH application ID:** 10441102
- **Project number:** 5U01DD001234-04
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Douglass Brooks Clayton
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** ALLCDC
- **Fiscal year:** 2022
- **Award amount:** $25,000
- **Award type:** 5
- **Project period:** 2019-09-01 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10441102

## Citation

> US National Institutes of Health, RePORTER application 10441102, Comp C Spina Bifida Urologic Protocol at Vanderbilt Children's Hospital (5U01DD001234-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10441102. Licensed CC0.

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