# Bioinformatics and Biostatistics Core

> **NIH NIH P50** · YALE UNIVERSITY · 2022 · $251,615

## Abstract

Project Summary
The goal of the Biostatistics and Bioinformatics Core (Core C) is to address the statistical design and analysis
needs of the Yale SPORE in Head and Neck Cancer (YHN-SPORE) Projects, the Cores, the Developmental
Research Program (DRP), and the Career Development Program (CDP). To accomplish this goal we have
assembled a highly interactive team of cancer biostatisticians and bioinformaticians who will work
collaboratively with basic, clinical, translational, and population science researchers to advance the frontiers of
cancer medicine. The specific aims of the Biostatistics and Bioinformatics Core are:
Aim 1​: ​Provide collaboration and consulting in the design, execution, monitoring and analysis of basic,
translational, population, and clinical studies for YHN-SPORE.
Aim 2​: ​Oversee and coordinate the collection, management, and analysis of data. Ensure that data collected
on all YHN-SPORE studies are of high quality, are evaluated with bioinformatic and statistical rigor, are
accessible within SPORE-affiliated collaborative groups, ultimately enabling the widest accessibility that is
appropriate given publication and privacy concerns.
For Aim 1, the Core will work closely with the investigators to analyze clinical trial and pre-clinical data, next
generation sequencing data, and bioinformatics data mining. Services provided by the Core will range from
planning and design activities to consulting on specific analytic questions. The Core will address the analytic
and informatics questions arising from the YHN-SPORE projects. The Core will rigorously design and monitor
clinical trials for safety, efficacy and futility. The Core will schedule regular meetings with the YHN-SPORE
investigators, and maintain an open-door policy for any biostatistical and bioinformatics questions. The Core
will conduct interim and final analyses, develop new statistical and bioinformatics methodology as needed,
provide timely suggestions to YHN-SPORE investigators, and thus play an important role in the entire study.
Biostatistics and Bioinformatics is also a key partner in the YHN-SPORE with representation on their Senior
Leadership Team and participation in all core meetings. For Aim 2, The Core will work with the Yale Cancer
Center (YCC), Yale Center for Analytical Sciences (YCAS), Fox Chase Cancer Center (FCCC) and its
quantitative cores to facilitate communication among YHN-SPORE researchers, creating and implementing
web-accessible databases for collecting, storing and accessing the various types of data (e.g. laboratory,
clinical, population, and genomic data) that will be generated for the YHN-SPORE projects. The Core is highly
integrated with the projects, and will have regular meetings with project investigators, as well as YCAS data
managers, to evaluate the data generated from the studies and ensure accurate and up-to-date data
management.
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## Key facts

- **NIH application ID:** 10441507
- **Project number:** 5P50DE030707-03
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Jeffrey Peter Townsend
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $251,615
- **Award type:** 5
- **Project period:** 2020-09-22 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10441507

## Citation

> US National Institutes of Health, RePORTER application 10441507, Bioinformatics and Biostatistics Core (5P50DE030707-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10441507. Licensed CC0.

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