# The Ohio Valley Node of the Clinical Trials Network

> **NIH NIH UG1** · UNIVERSITY OF CINCINNATI · 2021 · $33,244

## Abstract

Using Integrative Data Analysis to Examine the Impact of Psychosocial Treatments for
Black Cocaine Users Enrolled in the NIDA Drug Abuse Treatment Clinical Trials Network
(CTN)
Specific Aims
Recent reports reveal that the acceleration of opioid-involved overdose deaths for Black people
now outpaces that of White people.1 This increase is attributable to the presence of synthetic
opioids (fentanyl) in the cocaine supply in approximately one third of opioid overdose deaths.
The limited body of work available suggests that treatment effectiveness may vary across racial-
ethnic groups. Yet, only a subset of these studies have specifically looked at cocaine use. The
CTN provides a unique but underexplored collection of studies that can improve our knowledge
on effective psychosocial treatments for Black people who use cocaine. The proposed study will
combine data from 7 CTN treatment studies (total N = 1442 Black participants) that in
combination present mixed findings. Using multiple emerging measurement/data analysis
frameworks (integrative data analysis (IDA), meta-analysis of individual patient data (MIPD),
causal moderation analysis), the goal of the proposed study is to evaluate the
effectiveness of substance use disorder treatments for Black people who use cocaine.
The project has three specific aims:
Aim 1: Estimate scale scores of cocaine use severity while considering study-level
measurement non-invariance.
Aim 2: Compare the effectiveness of evidence-based treatment models for cocaine use severity.
Aim 3: Explore individual- and study-level moderators, such as concomitant opioid use, age,
sex, employment, pre-treatment psychiatric status, and retention to evaluate subgroup
differences in treatment effectiveness.

## Key facts

- **NIH application ID:** 10441828
- **Project number:** 3UG1DA013732-22S2
- **Recipient organization:** UNIVERSITY OF CINCINNATI
- **Principal Investigator:** T John WINHUSEN
- **Activity code:** UG1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $33,244
- **Award type:** 3
- **Project period:** 2021-07-01 → 2022-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10441828

## Citation

> US National Institutes of Health, RePORTER application 10441828, The Ohio Valley Node of the Clinical Trials Network (3UG1DA013732-22S2). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10441828. Licensed CC0.

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