# Yersinia Outer-Membrane-Vesicle Vaccines Against Pneumonic Plague

> **NIH NIH R01** · ALBANY MEDICAL COLLEGE · 2022 · $584,647

## Abstract

SUMMARY
 Yersinia pestis, the etiologic agent of plague, has been responsible for high mortality in several epidemics
throughout human history. Plague has been classified as a re-emerging disease by the World Health
Organization since there are several thousand reported cases of the disease worldwide annually and
multidrug-resistant Y. pestis strains occur in recent years. The plague bacillus has been used as a biological
weapon recorded in human history and is one of the more likely biological threats to be used by terrorists.
Currently, no licensed plague vaccines are available in Western world. Isolation of virulent F1-negative Y.
pestis strains from natural sources and the existence of lcrV polymorphisms in Yersinia may result in Y. pestis
variants that escape protective immunity induced by LcrV and F1 antigens. Therefore, vaccines solely based
upon LcrV and F1 antigens is insufficient to guarantee long-term defense against plague in humans. In order to
overcome the drawbacks of subunit vaccines composed of LcrV and F1 antigens, we propose to use Y.
pseudotuberculosis (Yptb) OMVs as an acellular vaccine against plague: (1) Construct Yptb strains which
robustly produce highly immunogenic self-adjuvanting OMVs carrying an array of Y. pestis protective antigens;
(2) Evaluate protective immunity of OMVs in rodents (mouse and rat). (3) Carefully decipher mechanisms of
immune protection induced by the Yersinia OMVs to provide fundamentals for rational plague vaccine
development. Finally, the success of this project will provide highly effective and safe plague vaccines for
humans.

## Key facts

- **NIH application ID:** 10441853
- **Project number:** 1R01AI162670-01A1
- **Recipient organization:** ALBANY MEDICAL COLLEGE
- **Principal Investigator:** Wei Sun
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $584,647
- **Award type:** 1
- **Project period:** 2022-01-25 → 2026-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10441853

## Citation

> US National Institutes of Health, RePORTER application 10441853, Yersinia Outer-Membrane-Vesicle Vaccines Against Pneumonic Plague (1R01AI162670-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10441853. Licensed CC0.

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