# Roles of CCR10 in regulation of IgA responses to SARS-CoV-2 infection

> **NIH NIH R21** · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2022 · $232,500

## Abstract

Summary
The novel coronavirus SARS-CoV-2 causes the COVID-19 pandemic. The virus infects through the
respiratory tracts. While most COVID-19 patients display no or mild clinical symptoms, a small
percentage develop severe immune-mediated pathological complications, which could lead to injury
and failure of the lung and various important organs and account for the majority of COVID-19 deaths.
Understanding how different components of the immune system are involved in the viral control and
pathological development is crucial for our understanding of pathogenesis of the disease and
developing preventative and therapeutic strategies. In this grant application, we propose to dissect
involvement of CCR10-regulated mucosal IgA antibody responses in SARS-CoV-2 infection clearance
versus immune-pathological development using mouse models in two specific aims. In the Aim 1, we
will determine the role of CCR10-regulated primary mucosal IgA responses in SARS-CoV-2-infection
clearance and immunopathological development. In the Aim 2, we will determine the role of CCR10-
regulated memory mucosal IgA responses in SARS-CoV-2 infection and immune-pathological
development. The findings of our proposed study will not only help our understanding of involvement of
mucosal IgA responses in clearance of the viral infection and pathogenesis of COVID-19 but also
provide a guide on future development of vaccination strategies to induce proper IgA response for the
disease prevention.

## Key facts

- **NIH application ID:** 10442019
- **Project number:** 1R21AI169430-01
- **Recipient organization:** UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
- **Principal Investigator:** YAN XIANG
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $232,500
- **Award type:** 1
- **Project period:** 2022-05-16 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10442019

## Citation

> US National Institutes of Health, RePORTER application 10442019, Roles of CCR10 in regulation of IgA responses to SARS-CoV-2 infection (1R21AI169430-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10442019. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*