# Claude D. Pepper Older Americans Independence Center at Yale

> **NIH NIH P30** · YALE UNIVERSITY · 2022 · $1,134,628

## Abstract

The overarching mission of the Yale Older Americans Independence Center (OAIC), established in 1992, is
to provide intellectual leadership and innovation for aging research that is directed at enhancing the
independence of older persons. The unifying theme of the Yale OAIC remains the investigation of multifactorial
geriatric conditions, encompassing single conditions resulting from multiple contributing factors or affecting
multiple outcome domains and multiple conditions occurring simultaneously. The central Yale OAIC
hypothesis is that geriatric conditions are determined by the co-occurrence of multiple predisposing and
precipitating factors. These conditions and factors, in turn, affect a range of health outcomes. The predisposing
factors may be at the genetic, molecular, physiologic, impairment, disease, or socio-demographic level, while
the precipitating factors may be behavioral, environmental, social, medical, or psychological. The Yale OAIC
theme requires designs and models (e.g. molecular, animal, and statistical) that inform the study of multiple,
simultaneously interactive factors and outcomes. As a prominent subtheme, the Yale OAIC also aims to
advance the science of clinical decision making in the face of trade-offs and multiple competing outcomes. This
includes developing strategies to elicit older persons’ health outcome priorities.
 The Specific Aims of the Yale OAIC are to: 1) foster the career development of future academic leaders,
from multiple disciplines, in aging research; 2) train investigators, biostatisticians and other methodologists in
the skills necessary to design, conduct, analyze, and disseminate findings from studies of multifactorial
geriatric conditions; 3) develop and disseminate design and analytic techniques for conducting studies of
multifactorial geriatric conditions; 4) develop strategies for recruiting into, and retaining, a broad spectrum of
older persons, including minorities, into studies of multifactorial geriatric conditions; 5) investigate the causative
mechanisms of, and develop and test effective treatments for, geriatric conditions from a multifactorial research
perspective; 6) develop strategies to enhance clinical decision making in the setting of multiple competing
outcomes; 7) encourage and facilitate interdisciplinary research (basic, translational and clinical) that connects
to our focus on multifactorial geriatric conditions; and 8) further strengthen collaborations with other OAICs.
The Yale OAIC cores include: 1) Leadership and Administrative; 2) Research Education; 3) Pilot/Exploratory
Studies; 4) Operations; and 5) Biostatistics. For the first one to two years of the next cycle, we propose to
support 3 Pepper Scholars, 3 pilot studies, 2 development projects, and 29 externally funded projects.
 The Yale OAIC has made outstanding progress during the current funding cycle, as evidenced by
publication of 411 manuscripts (with an additional 23 submitted) and receipt of more than $178 mill...

## Key facts

- **NIH application ID:** 10442398
- **Project number:** 5P30AG021342-20
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Thomas Michael Gill
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,134,628
- **Award type:** 5
- **Project period:** 2002-09-30 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10442398

## Citation

> US National Institutes of Health, RePORTER application 10442398, Claude D. Pepper Older Americans Independence Center at Yale (5P30AG021342-20). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10442398. Licensed CC0.

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