# Diversity Supplement

> **NIH NIH R35** · GEORGIA INSTITUTE OF TECHNOLOGY · 2021 · $72,562

## Abstract

Project Summary
The goal of this Diversity Supplement Application is to provide an in-depth research experience
and strengthen the scientific background of Paola Marquez-Gomez to enable her to access and
thrive at a graduate program or medical school. Toward this goal, Paola will work on an extension
project of the paneer award engineering an orthogonal Gαs-coupled Designer G protein-couple
receptor activated by designer drug (DREADD) to enable the multiplex activation of GPCR
signaling pathways in mammalian cells. This work is significant because multiplex activation of
GPCR signaling in mammalian cells would allow the study of GPCR signaling crosstalk and its
effect on cellular phenotype, and, in the future, animal behavior. This work is innovative because
it leverages experimental and chemoinformatics data to train a machine learning algorithm to
engineer the substrate specificity of GPCRs for which no crystal structure is available.

## Key facts

- **NIH application ID:** 10443343
- **Project number:** 3R35GM124871-05S1
- **Recipient organization:** GEORGIA INSTITUTE OF TECHNOLOGY
- **Principal Investigator:** Pamela Peralta-Yahya
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $72,562
- **Award type:** 3
- **Project period:** 2017-09-01 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10443343

## Citation

> US National Institutes of Health, RePORTER application 10443343, Diversity Supplement (3R35GM124871-05S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10443343. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*