# Chronic Renal Insufficiency Cohort Study IV (CRIC-4)

> **NIH NIH U01** · KAISER FOUNDATION RESEARCH INSTITUTE · 2022 · $769,609

## Abstract

PROJECT SUMMARY/ABSTRACT
Since 2002, the NIDDK has sponsored Phases 1-3 of the prospective Chronic Renal Insufficiency Cohort
(CRIC) Study, which enrolled a combined cohort of >5400 adults with chronic kidney disease (CKD) at seven
Clinical Centers to address the overarching goals of identifying risk factors for CKD progression and clarifying
the relationship between kidney dysfunction and the risks of subclinical and clinical cardiovascular events,
death, resource utilization and other patient-centered outcomes through June 2018. The proposed CRIC 2018-
2023 will leverage the existing efforts and success of the CRIC Study network by extending the follow-up for
the existing cohort and expanding into novel areas focused on more granular investigation of kidney function
trajectories and cardiovascular sub-phenotyping, among others. CRIC 2018-2023 will become an unparalleled
resource for the broader community that will enhance the science related to CKD to achieve the ultimate goal
of improving clinical and patient-centered outcomes. Specific Aims to be addressed by the Kaiser Permanente
Northern California/University of California, San Francisco Clinical Center are:
1. To re-enroll a high percentage of existing participants
2. To maintain high levels of participant retention
3. To collect exposure and outcome data, including remotely collected kidney function, cardiovascular
 function, questionnaires, physical measurements and specimens
4. To investigate and adjudicate cardiovascular and renal events
5. To enter data and process/ship biological specimens
6. To implement effective local quality assurance and quality control procedures
7. To monitor regularly data collection, data entry, and follow-up procedures
8. To participate in governance and oversight of CRIC
9. To publish and present findings from the CRIC Study, including integrative and other high-impact
manuscripts
10. To conduct CRIC ancillary studies
11. To engage investigators at the Clinical Center to assist in the local analysis of CRIC data, to develop and
 conduct ancillary studies, and to participate in parent study activities
12. To engage investigators in the broader scientific community to analyze data locally, to develop and conduct
 ancillary studies, and to participate in the parent study

## Key facts

- **NIH application ID:** 10443587
- **Project number:** 5U01DK060902-22
- **Recipient organization:** KAISER FOUNDATION RESEARCH INSTITUTE
- **Principal Investigator:** Alan S Go
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $769,609
- **Award type:** 5
- **Project period:** 2001-09-30 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10443587

## Citation

> US National Institutes of Health, RePORTER application 10443587, Chronic Renal Insufficiency Cohort Study IV (CRIC-4) (5U01DK060902-22). Retrieved via AI Analytics 2026-06-10 from https://api.ai-analytics.org/grant/nih/10443587. Licensed CC0.

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