# Development of Analysis Tools to Enhance Magnetomyographic Assessment of Pelvic Floor Muscles > **NIH NIH R01** · UNIV OF ARKANSAS FOR MED SCIS · 2022 · $342,000 ## Abstract Project Summary/Abstract During pregnancy and delivery women experience pelvic soft tissue injury. This injury is associated with the development of symptomatic pelvic floor disorders (PFDs) including pelvic organ prolapse, urinary, and fecal incontinence. One of the biggest barriers to preventing birth injury and the subsequent sequelae of PFDs is our lack of understanding of when and how injury occurs. Simulation models suggest that term delivery requires stretch to the maternal pelvic floor musculature to a degree greater than that which skeletal muscle can normally undergo without sustaining injury. Thus, with term vaginal birth, near universal injury would be expected. Previous studies have used anatomic and functional methodology to explore this neuromuscular injury, but we continue to lack a complete understanding of maternal pelvic floor injury and recovery patterns. We also possess limited knowledge of the changes which maternal soft tissues undergo during pregnancy, presumably to facilitate atraumatic birth. Our institution houses the SQUID Array for Reproductive Assessment (SARA) system, a novel and noninvasive tool to assess biomagnetic signals such as those created by depolarization occurring with muscle contraction. We propose to adapt SARA system to record the biomagnetic signals generated by the levator ani muscles (LAMs) of the maternal pelvic floor and apply advanced signal processing techniques to extract and characterize the LAM electrophysiology. These magnetomyographic (MMG) recordings will be used to study maternal pelvic floor neuromuscular function before and after delivery. Our project will be the first to comprehensively use MMG technology to assess the maternal LAMs. We will combine clinical, anatomic, and physiologic endpoints to improve our knowledge of maternal pelvic muscular adaptations and injury recovery patterns using a comprehensive protocol with which we have demonstrated promising preliminary data in small cohorts of nulligravidas and nulliparous gravidas. This proposal is in response to NIBIB’s PAR-19-158 Bioengineering Research Grants, where we apply a multidisciplinary integrative team approach to address the paucity of knowledge regarding maternal muscular adaptations and maternal LAM injury thus provide a framework for future innovation in injury prevention and recovery research. Our overall hypothesis is that MMG will allow detection of maternal LAMs adaptation during pregnancy and identification of injury and recovery patterns postpartum. Aim 1: To adapt biomagnetic technology based system to record high spatial temporal MMG LAM complex and apply advanced signal processing methods to extract relevant pelvic floor muscle parameters. Aim 2: To track and characterize changes in levator MMG signals with parturition comparing 3rd trimester pregnancy to early and late postpartum. Aim 3: To correlate MMG patterns of LAM birth injury and recovery and associate MMG evidence of injury with PFD symtpoms and inju... ## Key facts - **NIH application ID:** 10443695 - **Project number:** 5R01EB031589-02 - **Recipient organization:** UNIV OF ARKANSAS FOR MED SCIS - **Principal Investigator:** Hari Eswaran - **Activity code:** R01 (R01, R21, SBIR, etc.) - **Funding institute:** NIH - **Fiscal year:** 2022 - **Award amount:** $342,000 - **Award type:** 5 - **Project period:** 2021-07-15 → 2025-03-31 ## Primary source NIH RePORTER: https://reporter.nih.gov/project-details/10443695 ## Citation > US National Institutes of Health, RePORTER application 10443695, Development of Analysis Tools to Enhance Magnetomyographic Assessment of Pelvic Floor Muscles (5R01EB031589-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10443695. Licensed CC0. --- *[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*