# Animal Behavior & Neurophysiology

> **NIH NIH P50** · UNIVERSITY OF ROCHESTER · 2022 · $184,522

## Abstract

Project Summary: The URMC IDDRC Animal Behavior and Neurophysiology (ABN) Core will provide IDDRC
members with access to behavioral and neurophysiological assays in rodent models that harness the expertise
of the Core leadership and allow for investigation of the neural underpinnings of IDDs. The Core’s
Components in animal behavior and neurophysiology are already central to work being conducted by IDDRC
investigators, providing access to equipment, techniques, and analyses that are central to current
neuroscience research. By providing access to well established assays that are essential to IDD research, the
animal behavior component of the Core allows investigators to relate changes at the gene, cell, and circuit
level in the animal models to behaviors that may provide mechanistic insight into IDDs. Similarly, by providing
access to single neuron, multiunit, and population activity measures, the neurophysiology component of the
core allows investigators to further establish bridges that link changes in patterns of neuronal activity to
behavioral changes that may underlie a number of IDDs. Both components of the Core have continued to
advance and validate new technologies; both are also critical to the Research Project. The ABN Core will be
supported by dedicated administrative and technical faculty and staff to provide critical expertise in the design,
implementation, and analysis of both behavioral and neurophysiological assays critical to IDD research. To
achieve this, three Aims are proposed. Aim 1 is to provide vital access to resources (both equipment and
expertise) for carrying out behavioral and neurophysiological assays critical to IDDRC investigator research.
Aim 2 will provide technical and methodological guidance and support to generate data in both behavioral and
neurophysiological assays critical to IDDRC investigator research. Aim 3 will provide analysis and statistical
guidance and support to interpret data in both behavioral and neurophysiological assays critical to IDDRC
investigator research. Collectively, the ABN Core of the URMC IDDRC will allow investigators to perform
behavioral and neurophysiological assays in animal models to gain insight into the neural underpinnings of
IDDs. Through its interactions with other IDDRC Cores, it will advance the long-term goal of identifying
interventions and treatments at the cellular, neurophysiological, and behavioral levels.

## Key facts

- **NIH application ID:** 10445286
- **Project number:** 5P50HD103536-03
- **Recipient organization:** UNIVERSITY OF ROCHESTER
- **Principal Investigator:** Deborah A Cory-Slechta
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $184,522
- **Award type:** 5
- **Project period:** 2020-08-01 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10445286

## Citation

> US National Institutes of Health, RePORTER application 10445286, Animal Behavior & Neurophysiology (5P50HD103536-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10445286. Licensed CC0.

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