# The MyGoals for Healthy Aging Multi-Center Randomized Controlled Trial

> **NIH NIH R01** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2022 · $598,596

## Abstract

Poverty is associated with harsh living conditions, few opportunities to exercise, and poor access to healthy
food that collectively produce “wear and tear” on organ systems. Psychological stress increases the fragility of
neurons in the central nervous system, potentially producing both the loss of function and volume in areas of
the brain that are involved in maintaining homeostasis (e.g., blood glucose), planning tasks, executing tasks,
motivation, and emotional control. Psychological stress and poor nutrition can accelerate the aging process,
and may manifest as executive function deficits, diabetes, obesity, Alzheimer's disease/Alzheimer's disease-
related dementias (AD/ADRD), and early death. The mechanisms by which poverty-associated stress
accelerates aging are known, but there is no proven intervention to slow the rapid pace of aging among
impoverished families. Anti-poverty programs are a logical point of intervention.
An ongoing randomized-controlled trial (RCT), MyGoals for Employment Success, intervenes on both poverty
using proven employment incentives and on executive function deficits using a field-tested coaching program.
That study was designed to evaluate outcomes associated with executive function, economic well-being, and
social functioning. To evaluate outcomes associated with aging, additional intervention time and follow up are
needed because health outcomes tend to lag economic outcomes.
The National Institute on Aging provided one year of funding for cohort maintenance and to re-design MyGoals
for Employment Success into a healthy aging study with three years of intervention time, six years of follow up,
and health, aging, and cognition measures. This re-design was done in collaboration with leading
interdisciplinary experts using the Delphi method, a formalized process for understanding how to optimize
measure selection and the timing of measure collection. With their input, we propose an innovative RCT that
we call MyGoals for Healthy Aging. We will measure the effect of the intervention on psychological stress, diet,
sleep, mood, loneliness, height, weight, executive function, blood sugar, high-sensitivity C-reactive protein, and
gene methylation patterns. We will also store blood for future “freezer studies” that allow for more sophisticated
measures of human aging. In addition, we will maintain an ongoing dataset linked to electronic data so that it is
possible to measure outcomes beyond the time frame of the study, including future income and mortality by
cause of death. Completion of these aims will provide foundational evidence on the ability of social policy to
influence aging-related health outcomes; our ultimate goal is to test a novel intervention that might reduce or
eliminate disparities in chronic diseases including AD/ADRD.

## Key facts

- **NIH application ID:** 10446592
- **Project number:** 1R01AG073402-01A1
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Daniel Walker Belsky
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $598,596
- **Award type:** 1
- **Project period:** 2022-08-01 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10446592

## Citation

> US National Institutes of Health, RePORTER application 10446592, The MyGoals for Healthy Aging Multi-Center Randomized Controlled Trial (1R01AG073402-01A1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10446592. Licensed CC0.

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