# Combined bioprinting with stem cell technology to regenerate skin burn wounds

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $500,169

## Abstract

PROJECT SUMMARY
The skin (epidermis) is responsible for protecting the body and works as a specialized, vital defensive barrier.
Upon injury, the immediate response of the epidermis and its stem cells aims to reestablish local homeostasis.
Extensive injuries, often observed in burn patients, compromise the epidermal homeostasis, which leads to
dehydration, possible severe infections, and death. New therapeutic strategies designed to improve healing and
burn injuries are critically needed. Our translation-focused innovative strategy aims to develop mechanism-based
and material engineering-driven therapies to augment epidermal healing. Here, we are developing novel and
exciting biodegradable scaffolds for the controlled delivery of key recombinant proteins and cells to positively
reestablish an epidermal barrier and wound closure. We propose to study how this novel therapeutic strategy
affects the skin stem cells and wound healing process. Furthermore, we will determine the therapeutic
effectiveness of 3D tissue engineering on burn wounds using bioprinting technology. Our positive results will
improve the mechanistic understanding of how patient-originated stem cells and epidermal cells along with 3D
bioprinting contribute to the healing of burn wounds. By accomplishing these specific aims, we will aid in the
management of burn patients, using limited donor tissues and help to reduce burn patients’ recovery time.

## Key facts

- **NIH application ID:** 10447161
- **Project number:** 5R01GM143938-02
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Marco C Bottino
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $500,169
- **Award type:** 5
- **Project period:** 2021-08-01 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10447161

## Citation

> US National Institutes of Health, RePORTER application 10447161, Combined bioprinting with stem cell technology to regenerate skin burn wounds (5R01GM143938-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10447161. Licensed CC0.

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