# Pittsburgh Older Americans Independence Center

> **NIH NIH P30** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2022 · $1,272,919

## Abstract

Overall Component Project Summary/Abstract
The overall goals of the Pittsburgh Claude D. Pepper Older American Independence Center (OAIC), funded
since 2004, are to address the critical need to improve mobility, balance and falls risk, both through improved
understanding of their causes and through development of preventive and therapeutic interventions. With this
renewal we also will extend our work into new and high potential areas and bring several innovations to our
activities and Cores.
Specific aims for the next 5 years are to:
1) Promote multidisciplinary research that will elucidate the causes, consequences and management of age-
related changes in mobility and balance.
2) Further extend our work into two high potential areas: a) translational investigations to examine interactions
between multiple systems at the level of molecules, signaling systems, cells and their organelles, and tissues,
as they impact mobility and balance in living organisms, and b) impact on individual older adults of health
system, community and long-term care interventions to enhance mobility and balance.
3) Train young investigators from multiple disciplines to become national leaders in age-related mobility and
balance problems in a vibrant, collaborative environment and build a translational sciences workforce through
collaborative basic and clinical sciences team mentoring.
4) Serve as a champion and invaluable resource for investigators, research programs, institutions, OAICs and
the public in the area of mobility and balance in older adults.
Our accomplishments and plans build on our fundamental values: 1) a cohesive theme that accommodates
multiple approaches and opportunities to address critical gaps in knowledge, 2) a commitment to
multidisciplinary research, 3) a stable organization that grows and evolves, and 4) rigorous preparation of
future investigators and leaders.
To accomplish these aims, our OAIC is built around 7 cores. In addition to the Leadership and Administrative
Core (LAC) and a Research Education Component (REC), we have a Pilot and Exploratory Studies Core
(PESC) and 4 resource Cores: 1) a Clinical and Populations Outcomes Core (CPOC), 2) an Integrative
Systems Core (ISC), 3) a Data Management, Analysis and Informatics Core (DMAIC) and, new for this cycle, a
Biology of Mobility and Aging Core (BMAC). In the first year of the renewal, we will support 3 Pepper Scholars,
5 pilot projects, and 4 developmental projects that illustrate the scope and innovation of our work.

## Key facts

- **NIH application ID:** 10447577
- **Project number:** 5P30AG024827-18
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** SUSAN L GREENSPAN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,272,919
- **Award type:** 5
- **Project period:** 2004-09-30 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10447577

## Citation

> US National Institutes of Health, RePORTER application 10447577, Pittsburgh Older Americans Independence Center (5P30AG024827-18). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10447577. Licensed CC0.

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